硅酸铝钙钠盐 | 1344-01-0

• 物质功能分类: 无机化工 - 无机盐 - 硅化物及硅酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 后过渡金属氧阴离子化合物
• 中文名称: 硅酸铝钙钠盐
• 英文名称: Silicic acid, aluminum calcium sodium salt
• 英文别名: aluminum;calcium;sodium;silicate
• CAS: 1344-01-0
• 化学式: AlCaNaO4Si+2
• 分子量: 182.13
• InChiKey: IDZYHGDLWGVHQM-UHFFFAOYSA-N

物化性质

• 密度：
  2.42[at 20℃]
• 物理描述：
  DryPowder
• 稳定性/保质期：
  Low melting solids or colorless, volatile liquids. /Alkylaluminum halides/

计算性质

• 辛醇/水分配系数(LogP)：
  -8.89
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.2
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

毒理性

• 致癌性证据

A4；不可归类为人类致癌物。/铝金属和难溶化合物/

A4; Not classifiable as a human carcinogen. /Aluminum metal and insoluble compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

在含有黄曲霉毒素的玉米配制的饲料中添加0.5%的水合钠钙铝硅酸盐，可以减少霉菌毒素对体重增加和饲料摄入的负面影响。在饲喂了含有该铝硅酸盐吸附剂的污染饲料的猪的肝脏切片中，通常与黄曲霉毒素消费相关的肝细胞变化在组织病理学上无法被检测到。

Adding 0.5% hydrated sodium calcium aluminosilicate to diets formulated with aflatoxin contaminated corn reduced the detrimental effects of the mycotoxin on live weight gains and feed intake. Hepatocellular changes normally associated with aflatoxin consumption could not be detected histopathologically in liver sections from pigs fed contaminated diets plus the aluminosilicate sorbent.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 相互作用

以前的研究已经证明，水合钠钙铝硅酸盐（HSCAS，或NovaSil®）能够紧密地结合并固定动物胃肠道中的黄曲霉毒素。这种作用显著降低了这些食物和饲料来源毒素的生物利用度和毒性。由于AfB1在大鼠中是一种强烈的发展毒素，本研究的目标是评估HSCAS和一种常见沸石（斜发沸石）保护胎儿发育的能力。在妊娠期间，将铝硅酸盐HSCAS 1、HSCAS 2和斜发沸石以0.5%（w/w）的比例添加到饮食中，并给予Sprague-Dawley大鼠。在妊娠第6-13天，实验动物口服AfB1，剂量为2 mg/kg bw，溶解在玉米油中，在第20天对母体、发育和病理学参数进行评估。单独的粘土并无毒性；AfB1单独导致75%的母体死亡率，98%的胚胎吸收和典型的肝脏和肾脏病变。用HSCAS 1和HSCAS 2（加AfB1）处理的动物与对照组相似。

Previous research has demonstrated that hydrated sodium calcium aluminosilicate (HSCAS, or NovaSilÑ) tightly binds and immobilizes aflatoxins in the gastrointestinal tract of animals. This action markedly reduces the bioavailability and toxicity of these food and feedborne poisons. Since AfB1 is a potent developmental toxin in rats, /the/ objectives in this study were to evaluate the ability of HSCAS and a common zeolite (clinoptilolite) to protect the developing fetus. Aluminosilicates, HSCAS 1, HSCAS 2, and cliniptilolite, were added to the diet at a level of 0.5% (w/w) and administered to Sprague-Dawley rats throughout pregnancy. Test animals were dosed orally with AfB1 at 2 mg/kg bw dissolved in corn oil during gestation days 6-13, and dams and /fetuses/ were evaluated for various maternal, developmental and histological parameters on day 20. Clays, by themselves, were not toxic; AfB1 alone resulted in 75% maternal mortality, 98% embryonic resorptions and typical liver and kidney lesions. Animals treated with HSCAS 1 and HSCAS 2 (plus AfB1) were comparable to controls. /Hydrated sodium calcium aluminosilicate/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

/其他毒性信息/ ... 在一项研究中，对75个随机选取的尸检案例的肺部颗粒物进行了自动扫描电子显微镜/能量色散X射线微分析系统的分析。发现每克干肺组织中平均有6.13亿个外源性颗粒物，主要颗粒类别为二氧化硅、滑石粉、铝硅酸盐和金红石。在第二个研究中，对50个随机选取的尸检案例的肺部进行了重量分析和X射线衍射分析。高温灰化法制备的样本中，总颗粒物的中位数为0.33克；而使用硝酸消化的样本中为0.41克。所有案例中石英的中位量为0.044克。之前通过自动扫描电子显微镜分析的75个肺部样本中的18个样本也用重量分析和X射线衍射分析进行了分析。 ... /铝硅酸盐/

/OTHER TOXICITY INFORMATION/ ...In one study, individual particles from the lungs of 75 randomly selected autopsy cases were analyzed using an automated scanning electron microscopy /energy dispersive X-ray microanalysis system. An average of 613 million particles, of exogenous origin, per gram of dry lung tissue were found, the major classes of particles being silica, talc, aluminum silicates, and rutile. In the second study, lungs from 50 randomly selected autopsy cases were analyzed using gravimetric and X-ray diffraction analysis. The median total particulate material was 0.33 g, for cases in which samples were prepared by high temperature ashing, and 0.41 grams, for those in which nitric acid digestion was used. The median amount of quartz for all cases, was 0.044 g. Samples of eighteen of the 75 lungs previously analyzed by automated scanning electron microscopy were also analyzed using gravimetric and X-ray diffraction analysis. ... /Aluminum Silicates/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：急性暴露/家兔（每只2-3公斤，性别未给出，每组1只处理），禁食24小时后，通过胃管给予粉状、结晶状或颗粒状的硅酸铝钠（32、16、5和1克/公斤）在半固体琼脂或1克明胶胶囊中。硅酸铝钠在摄入后1小时或2小时进行检查时，导致胃内壁轻微发白和中等水肿，而没有显著的微病理变化。/硅酸铝钠/

/LABORATORY ANIMALS: Acute Exposure/ Rabbits (2-3 kg each, sex not given, 1/treatment group), fasted for 24 hr, were administered powdered, crystalline, or pelletized sodium aluminosilicate (32, 16, 5, and 1 g/kg) in semi/solid agar or in 1 gm gelatin capsules by gastric intubation. Sodium aluminosilicate caused slight blanching and moderate edema of the inner stomach wall without remarkable micropathology when examined either 1 or 2 hours following ingestion. /Sodium aluminosilicate/

来源:Hazardous Substances Data Bank (HSDB)