1,3-Dioxa-8-aza-spiro[4.5]decane | 34400-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 1,3-Dioxa-8-aza-spiro[4.5]decane
• 英文别名: 1,3-Dioxa-8-azaspiro[4.5]decane
• CAS: 34400-06-1
• 化学式: C₇H₁₃NO₂
• mdl: MFCD19225706
• 分子量: 143.186
• InChiKey: FECVUROJJMVWHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(3-Bromophenyl)-7-(6-chloropyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine 、 1,3-Dioxa-8-aza-spiro[4.5]decane 以 二甲基亚砜 为溶剂， 生成 5-(3-Bromo-phenyl)-7-[6-(1,3-dioxa-8-aza-spiro[4.5]dec-8-yl)-pyridin-3-yl]-pyrido[2,3-d]pyrimidin-4-ylamine
  参考文献：
  名称：

  Adenosine kinase inhibitors: polar 7-Substitutent of pyridopyrimidine derivatives improving their locomotor selectivity

  摘要：

  We have discovered that polar 7-substituents of pyridopyrimidine derivatives affect not only whole cell AK inhibitory potency. but also selectivity in causing locomotor side effects in vivo animal models. We have identified compound, 1o, which has potent whole cell AK inhibitory potency, analgesic activity and minimal reduction of locomotor activity. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00642-5

文献信息

• 1,6-DIHYDRO-1,3,5,6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME
  申请人：Pitts William J.

  公开号：US20100210629A1

  公开（公告）日：2010-08-19

  The present invention provides for tricyclic compounds having the formula (I), wherein R 1 , R 2 , R 5 , R 6 , R 7 , and R 8 are as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.

  本发明提供了具有式（I）的三环化合物，其中R1、R2、R5、R6、R7和R8如本文所述。本发明还提供了包含这些化合物的药物组合物，以及使用这些化合物治疗炎症和免疫性疾病的方法。
• US8268855B2
  申请人：——

  公开号：US8268855B2

  公开（公告）日：2012-09-18
• Adenosine kinase inhibitors: polar 7-Substitutent of pyridopyrimidine derivatives improving their locomotor selectivity
  作者：Guo Zhu Zheng、Yue Mao、Chih-Hung Lee、John K. Pratt、John R. Koenig、Richard J. Perner、Marlon D. Cowart、Gregory A. Gfesser、Steve McGaraughty、Katharine L. Chu、Chang Zhu、Haixia Yu、Kathy Kohlhaas、Karen M. Alexander、Carol T. Wismer、Joseph Mikusa、Michael F. Jarvis、Elizabeth A. Kowaluk、Andrew O. Stewart

  DOI：10.1016/s0960-894x(03)00642-5

  日期：2003.9

  We have discovered that polar 7-substituents of pyridopyrimidine derivatives affect not only whole cell AK inhibitory potency. but also selectivity in causing locomotor side effects in vivo animal models. We have identified compound, 1o, which has potent whole cell AK inhibitory potency, analgesic activity and minimal reduction of locomotor activity. (C) 2003 Elsevier Ltd. All rights reserved.