[2,4,6-Trimethyl-5-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyridin-3-yl]-acetic acid | 533938-51-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: [2,4,6-Trimethyl-5-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyridin-3-yl]-acetic acid
• 英文别名: 2-[2,4,6-Trimethyl-5-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methyl]pyridin-3-yl]acetic acid
• CAS: 533938-51-1
• 化学式: C₁₈H₁₅F₃N₂O₂S
• 分子量: 380.391
• InChiKey: PFNREKUNOGSYRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Substituted heteroarylalkanoic acids
  申请人：The Institutes for Pharmaceutical Discovery, Inc. A Corporation of the State of Delaware

  公开号：US20030166668A1

  公开（公告）日：2003-09-04

  Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

  揭示了以下公式D-A-C(O)R′的取代杂环烷基丙酸，其中D、A和R′在此处定义。这些化合物在治疗糖尿病引起的慢性并发症方面非常有用。还公开了含有这些化合物的药物组合物以及使用这些化合物的治疗方法，以及它们的合成方法。
• Substituted Heteroarylalkanoic Acids
  申请人：Van Zandt Michael C.

  公开号：US20090163535A1

  公开（公告）日：2009-06-25

  Disclosed are substituted heteroarylalkanoic acids of the following formula D-A-C(O)R′, where D, A, and R′ are defined herein. These compounds are useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.

  本发明揭示了下式D-A-C(O)R′的取代杂环烷基脂肪酸，其中D，A和R′在此定义。这些化合物可用于治疗由糖尿病引起的慢性并发症。此外，还揭示了含有这些化合物的药物组合物和使用这些化合物的治疗方法，以及它们的合成方法。
• SUBSTITUTED HETEROARYLALKANOIC ACIDS AND THEIR USE AS ALDOSE REDUCTASE INHIBITORS
  申请人：The Institutes for Pharmaceutical Discovery, LLC

  公开号：EP1444228B1

  公开（公告）日：2008-05-21
• US7361671B2
  申请人：——

  公开号：US7361671B2

  公开（公告）日：2008-04-22
• [EN] SUBSTITUTED HETEROARYLALKANOIC ACIDS<br/>[FR] ACIDES HETEROARYLALKANOIQUES SUBSTITUES
  申请人：INST FOR PHARM DISCOVERY INC

  公开号：WO2003044015A2

  公开（公告）日：2003-05-30

  Disclosed are substituted heteroarylalkanoic acids acids of the following formula D-A-C (O)R' where D, A, and R' are defined herein. These compounds are useful in the treatement of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.