1-ethyl-3-(5-(5-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl)urea | 1186109-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: 1-ethyl-3-(5-(5-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl)urea
• 英文别名: 1-ethyl-3-[5-[5-(2-oxo-3H-1,3,4-oxadiazol-5-yl)pyrazin-2-yl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]urea
• CAS: 1186109-95-4
• 化学式: C₂₂H₁₇N₉O₄
• 分子量: 471.435
• InChiKey: YHIJQCHNQQVVEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  169
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• [EN] HETEROCYCLIC UREA DERIVATIVES USEFUL FOR TREATMENT OF BACTERIAL INFECTION<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES DE L'URÉE UTILES POUR LE TRAITEMENT D'UNE INFECTION BACTÉRIENNE
  申请人：ASTRAZENECA AB

  公开号：WO2011024004A1

  公开（公告）日：2011-03-03

  Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  化合物的化学式（I）及其药用盐已被描述。还描述了它们的制备方法、含有它们的药物组合物、它们作为药物的用途以及它们在治疗细菌感染中的用途。
• [EN] HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF-211<br/>[FR] DÉRIVÉS D'URÉE HÉTÉROCYCLIQUE ET LEURS PROCÉDÉS D'UTILISATION-211
  申请人：ASTRAZENECA AB

  公开号：WO2009106885A1

  公开（公告）日：2009-09-03

  Chemical Compounds Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  化学化合物 公式(I)的化合物及其药用可接受的盐被描述。还描述了它们的制备方法、含有它们的药物组合物、它们作为药物的使用以及它们在治疗细菌感染中的用途。
• HETEROCYCLIC UREA DERIVATIVES AND METHODS OF USE THEREOF-211
  申请人：Bist Shanta

  公开号：US20120101100A1

  公开（公告）日：2012-04-26

  Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

  本文描述了化合物公式（I）及其药学上可接受的盐。还描述了它们的制备过程，包含它们的制药组合物，它们作为药物的用途以及它们在治疗细菌感染方面的用途。