6-methyl-4a,7a-dihydrothieno[2,3-d]pyrimidin-4(3H)-one | 1273578-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 6-methyl-4a,7a-dihydrothieno[2,3-d]pyrimidin-4(3H)-one
• 英文别名: 6-methyl-4a,7a-dihydro-3H-thieno[2,3-d]pyrimidin-4-one
• CAS: 1273578-08-7
• 化学式: C₇H₈N₂OS
• mdl: MFCD18800408
• 分子量: 168.22
• InChiKey: YTFKDBYDGNHOSM-UHFFFAOYSA-N

物化性质

• 沸点：
  328.4±52.0 °C(Predicted)
• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

文献信息

• [EN] FURANO- AND THIENOPYRIMIDINES AS NEUROKINASE INHIBITORS<br/>[FR] FURANO- ET THIENOPYRIMIDINES EN TANT QU'INHIBITEURS DE LA NEUROKINASE
  申请人：LUNDBECK & CO AS H

  公开号：WO2003064428A1

  公开（公告）日：2003-08-07

  The invention provides in one embodiment the use of a compound represented by the general formula I wherein the variable groups are as defined in the claims or a pharmaceutically acceptable acid addition salt thereof for the preparation of a medicament for the treatment of Parkinson's Disease, dementia such as age related dementia, HIV-1 associated dementia, AIDS dementia complex, HIV encephalopathy and senile dementia of the Alzheimer's type and memory disorders, cerebral ischemias and spinal cord ischemias, ischemias following stroke or traumatic injuries of the brain or the spinal cord, Huntington Chorea, multiple sclerosis, glaucoma, promotion of survival of transplanted cells, ALS/Motor neuron Disease, neuronal trauma or age related macular degeneration. The patent provides in another embodiment for novel compounds of general formula I. The patent provides in yet another embodiment for a pharmaceutical composition comprising a compound of general formula I. The compounds of the invention are neurokinase inhibitors.