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    首页 分子通 ethyl (1R,12S,14S,15S)-14-hydroxy-4,14-dimethyl-10-oxo-3,11-dioxatetracyclo[7.5.1.02,6.012,15]pentadeca-2(6),4,8-triene-5-carboxylate

    ethyl (1R,12S,14S,15S)-14-hydroxy-4,14-dimethyl-10-oxo-3,11-dioxatetracyclo[7.5.1.02,6.012,15]pentadeca-2(6),4,8-triene-5-carboxylate | 1204326-63-5

    分子结构分类

    有机化合物 - 有机杂环化合物 - 环七呋喃
    中文名称
    ——
    中文别名
    ——
    英文名称
    ethyl (1R,12S,14S,15S)-14-hydroxy-4,14-dimethyl-10-oxo-3,11-dioxatetracyclo[7.5.1.02,6.012,15]pentadeca-2(6),4,8-triene-5-carboxylate
    英文别名
    ——
    ethyl (1R,12S,14S,15S)-14-hydroxy-4,14-dimethyl-10-oxo-3,11-dioxatetracyclo[7.5.1.02,6.012,15]pentadeca-2(6),4,8-triene-5-carboxylate化学式
    CAS
    1204326-63-5
    化学式
    C18H20O6
    mdl
    ——
    分子量
    332.353
    InChiKey
    GBQNYOYLQPXSRH-CQEJWKIFSA-N
    BEILSTEIN
    ——
    EINECS
    ——
    • 物化性质
    • 计算性质
    • ADMET
    • 安全信息
    • SDS
    • 制备方法与用途
    • 上下游信息
    • 反应信息
    • 文献信息
    • 表征谱图
    • 同类化合物
    • 相关功能分类
    • 相关结构分类

    计算性质

    • 辛醇/水分配系数(LogP)：
      1.7
    • 重原子数：
      24
    • 可旋转键数：
      3
    • 环数：
      4.0
    • sp3杂化的碳原子比例：
      0.56
    • 拓扑面积：
      86
    • 氢给体数：
      1
    • 氢受体数：
      6

    上下游信息

    • 上游原料
      中文名称 英文名称 CAS号 化学式 分子量

    反应信息

    • 作为产物：
      描述：
      ethyl 5-[(4S,5S)-5-[[(2S)-4-ethenyl-5-oxo-2H-furan-2-yl]methyl]-2,2,5-trimethyl-1,3-dioxolan-4-yl]-2-methylfuran-3-carboxylate 在 水 、 三氟乙酸 作用下， 反应 0.25h， 以85%的产率得到ethyl (1R,12S,14S,15S)-14-hydroxy-4,14-dimethyl-10-oxo-3,11-dioxatetracyclo[7.5.1.02,6.012,15]pentadeca-2(6),4,8-triene-5-carboxylate
      参考文献：
      名称：
      An intramolecular [4+3]-cycloaddition approach to rameswaralide inspired by biosynthesis speculation
      摘要：
      A concise synthesis of the polycycle 27, which incorporates the 5,5,7-tricyclic ring core of rameswaralide 1, using a biogenetically inspired acid-catalysed [4+3]-cycloaddition approach starting from the furano-butenolide 26 is described, namely, 26-28/29-27. Under thermal conditions, the same furanobutenolide 26 gives the alternative polycyclic compound 35, resulting from a [4+2]-cycloaddition involving the furan as dienophile. (C) 2009 Elsevier Ltd. All rights reserved.
      DOI：
      10.1016/j.tetlet.2009.10.046
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    文献信息

    • An intramolecular [4+3]-cycloaddition approach to rameswaralide inspired by biosynthesis speculation
      作者：Gerald Pattenden、Johan M. Winne
      DOI：10.1016/j.tetlet.2009.10.046
      日期：2009.12
      A concise synthesis of the polycycle 27, which incorporates the 5,5,7-tricyclic ring core of rameswaralide 1, using a biogenetically inspired acid-catalysed [4+3]-cycloaddition approach starting from the furano-butenolide 26 is described, namely, 26-28/29-27. Under thermal conditions, the same furanobutenolide 26 gives the alternative polycyclic compound 35, resulting from a [4+2]-cycloaddition involving the furan as dienophile. (C) 2009 Elsevier Ltd. All rights reserved.
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    同类化合物

    [2-二(2,4-二叔-丁基苯氧基)磷烷氧基-3,5-二叔-丁基-苯基]-氯-钯 N-(2-氰基乙基)-N-(2-吗啉-4-基乙基)-4-羰基-9,10-二氢-4H-苯并[4,5]环庚三烯并[1,2-b]呋喃-3-甲酰胺盐酸 N-(2-(二乙胺)乙基)-4-((2-(二乙胺)乙基)氨基)-9,10-二氢-4-羟基-4H-苯并(4,5)环庚三烯并[1,2-b]呋喃-3-甲酰胺 N,N-二乙基-4-羰基-9,10-二氢-4H-苯并[4,5]环庚三烯并[1,2-b]呋喃-3-甲酰胺 6H-2-氧杂薁-6-酮 5-甲基-2,3-二氢-7H-呋喃并[3,2-g]色烯-7-酮 5-异丙基-3-(甲氧羰基)-2H-环庚烷[b]呋喃-2-酮 3-乙酰基-2H-环庚并[b]呋喃-2-酮 3-(甲氧羰基)-2H-环庚[b]呋喃-2-酮 3,5,8-三甲基薁并[6,5-b]呋喃 2H-环戊并(b)呋喃-2-酮 2,7,8,9-四氢-6-甲基-9-亚甲基-2-氧代薁并[4,5-b]呋喃-3-甲醛 (8R)-1,5,8-三甲基-7,8-二氢-6H-薁并[7,6-D]呋喃-2-酮 (5aR,6S)-rel-(-)-5,5a,6,10-四氢-5a,6-二甲基-4H-苯并(5,6)环庚并(1,2-b)呋喃 (3R,5Z,7E)-3,25-二羟基-9,10-裂胆甾-5,7,10-三烯-23-酮 (2Z)-3-甲基-N-苯基-2H-环庚并[b]呋喃-2-亚胺 6a-isopropyl-5,6,6a,7,8,9a-hexahydro-4H-azuleno[4,5-b]furan-9-one 4-oxo-5,6,7,8-tetrahydro-4H-cyclohepta[b]furan-3-carboxylic acid 8-(2'-methoxy-2'-propyl)cycloheptafuran 8-(1'-methoxy-1'-phenylmethyl)cycloheptafuran 8-(1',1'-dimethoxymethyl)cycloheptafuran 7-acetyl-2,4-dimethyl-9,10-dimethoxyindolo[2,3-h]-1-oxazulenium perchlorate 1,3-dimethyl-5,6,7,8-tetrahydro-4H-cyclohepta[c]furan-4-one 6-Hydroxy-1,3-dimethyl-5-trifluoroacetyl-6-trifluoromethyl-5,6,7,8-tetrahydro-4H-cycloheptenofuran-4,8-dione diethyl 2-oxo-2H-cycloheptafuran-3-ylmethylphosphonate 5,6,7,8-tetrahydro-4H-5,8-methanocyclohepta[b]furan-4-one furanoplagiochilal ethyl 4-oxo-5,6,7,8-tetrahydro-4H-cyclohepta[b]furan-3-carboxylate 6-isopropyl-2H-cycloheptafuran-2-one 3-Methylsulfonyl-5-propan-2-ylcyclohepta[b]furan-2-one 3-Methylsulfinyl-5-propan-2-ylcyclohepta[b]furan-2-one ethyl 8-methylthio-cyclohepta-furan-2-carboxylate ethyl 2-methylthio-4,5-dihydro(3H)benzocyclohepta<2,1-c>furan-9-carboxylate 3,5-dibromo-5,6,7,8-tetrahydro-2-phenyl-4H-cyclohepta[b]furan 3-bromo-2-(p-tolyl)-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-b]furan 3-bromo-2-(3,4-dimethoxyphenyl)-5,6-dihydro-4H-benzo[6,7]cyclohepta[1,2-b]furan 5-oxatetracyclo[6.6.1.0(2,6).0(9,14)]pentadeca-2(6),3,9,11,13-pentaene-4-carbaldehyde 3-cyano-2H-cycloheptafuran-2-imine 2-furan-3-yl-3-methyl-5,6,7,8-tetrahydro-4H-cyclohepta[b]furan 2-(4-nitrophenyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]furan-6-ol 3-[(E)-1,3-dimethyl-5,6,7,8-tetrahydro-4H-cyclohepta[c]furan-4-ylidene]-4-isopropylidentetrahydrofuran-2,5-dione 6H-benzo[6,7]cyclohepta[1,2-b]furan-6-one 5,6,7,8-tetrahydro-1-butyl-4H-cycloheptafuran 5,6,7,8-tetrahydro-1-propyl-4H-cycloheptafuran 5,6,7,8-tetrahydro-1-hexyl-4H-cycloheptafuran 5,6,7,8-tetrahydro-1-heptyl-4H-cycloheptafuran 4-chloroazuleno[4,5-c]furan 3-(4-pyridinyl)-2H-cyclohepta[b]furan-2-one 1,3-bis[bis(2-oxo-2H-cyclohepta[b]furan-3-yl)methyl]benzene 3-(N-trifluoromethanesulfonyl-1,4-dihydro-4-pyridyl)-2H-cyclohepta[b]furan-2-one

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