N-(2-Bromo-1,1,2,2-tetrafluoro-ethyl)-2,2,2-trifluoro-acetimidoyl fluoride | 135041-68-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 亚胺酰卤
• 英文名称: N-(2-Bromo-1,1,2,2-tetrafluoro-ethyl)-2,2,2-trifluoro-acetimidoyl fluoride
• 英文别名: N-(2-bromo-1,1,2,2-tetrafluoroethyl)-2,2,2-trifluoroethanimidoyl fluoride
• CAS: 135041-68-8
• 化学式: C₄BrF₈N
• 分子量: 293.942
• InChiKey: BBCWITGAKYQYTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-(2-Bromo-1,1,2,2-tetrafluoro-ethyl)-2,2,2-trifluoro-acetimidoyl fluoride 在 水 作用下， 反应 4.0h， 以70%的产率得到N-(2-Bromo-1,1,2,2-tetrafluoro-ethyl)-2,2,2-trifluoro-acetamide
  参考文献：
  名称：

  Synthesis of novel perhalo-1,3-heterodienes from N-bromoperhalo-1-alkanimines

  摘要：

  The hydrolysis of several perhalo-1-bromo-3-aza-3-alkenes R(x)CF = NCF2CF2Br, R(x) = CF3, C2F5, ClCF2) affords the corresponding acid amide (R(x)CONHCF2CF2Br) in excellent yield. Dehydrofluorination of the amides using active KF gives the novel 1,3-heterodienes, perhalo-1-bromo-3-aza-4-oxo-2-alkenes (R(x)CON = CFCF2Br), in high yield. Details on the synthesis and properties of the new compounds are given along with some reaction chemistry of the dienes.

  DOI：

  10.1021/jo00018a010

文献信息

• Halogen exchange reactions of perhalo-3-azaalkenes and their subsequent dehalogenation to form hetero-1,3-dienes
  作者：Michael I. Cook、Darryl D. Desmarteau

  DOI：10.1016/s0022-1139(00)81252-x

  日期：1991.11

  Treatment of the perhalogenated azaalkenes, RxCF = NCF2CFXBr (R(x) = CF3, C2F5, ClCF2; X = F, CF3) with AlCl3 readily produces new imines of the type RxCCl = NCCl2CFXBr and RxCCl2N = CClCFXBr. Dehalogenation of these new imines using activated zinc dust affords a series of novel hetero-1,3-dienes (RxCCl = NCCl = CFX).