Tert-butyl 2-(2-acetylhydrazinyl)-3-methyl-1,8-diazaspiro[4.5]dec-1-ene-8-carboxylate | 1234481-59-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: Tert-butyl 2-(2-acetylhydrazinyl)-3-methyl-1,8-diazaspiro[4.5]dec-1-ene-8-carboxylate
• 英文别名: tert-butyl 2-(2-acetylhydrazinyl)-3-methyl-1,8-diazaspiro[4.5]dec-1-ene-8-carboxylate
• CAS: 1234481-59-4
• 化学式: C₁₆H₂₈N₄O₃
• 分子量: 324.423
• InChiKey: MBWSCPSFTKVPLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  83
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Tert-butyl 2-(2-acetylhydrazinyl)-3-methyl-1,8-diazaspiro[4.5]dec-1-ene-8-carboxylate 在 吡啶 作用下， 反应 0.5h， 生成 3,7-Dimethylspiro[6,7-dihydropyrrolo[2,1-c][1,2,4]triazole-5,4'-piperidine]
  参考文献：
  名称：

  N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc

  摘要：

  Previously unreported N-Boc 4-nitropiperidine was prepared in two steps from N-Boc-piperidone. The synthetic utility of this new intermediate was demonstrated by the development of a new and simple route to spirolactam piperidines. Further synthetic work involving a challenging triazole cyclisation allowed the preparation of a spiropiperidine analogue of the eastern part of maraviroc. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.046
• 作为产物：
  描述：

  Tert-butyl 3-methyl-2-sulfanylidene-1,8-diazaspiro[4.5]decane-8-carboxylate 、 乙酰肼 在 吡啶 、 mercury dichloride 作用下， 以 三乙胺 为溶剂， 反应 1.0h， 以47%的产率得到Tert-butyl 2-(2-acetylhydrazinyl)-3-methyl-1,8-diazaspiro[4.5]dec-1-ene-8-carboxylate
  参考文献：
  名称：

  N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc

  摘要：

  Previously unreported N-Boc 4-nitropiperidine was prepared in two steps from N-Boc-piperidone. The synthetic utility of this new intermediate was demonstrated by the development of a new and simple route to spirolactam piperidines. Further synthetic work involving a challenging triazole cyclisation allowed the preparation of a spiropiperidine analogue of the eastern part of maraviroc. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.046

文献信息

• N-Boc 4-nitropiperidine: preparation and conversion into a spiropiperidine analogue of the eastern part of maraviroc
  作者：Philip Mullen、Hugues Miel、M. Anthony McKervey

  DOI：10.1016/j.tetlet.2010.04.046

  日期：2010.6

  Previously unreported N-Boc 4-nitropiperidine was prepared in two steps from N-Boc-piperidone. The synthetic utility of this new intermediate was demonstrated by the development of a new and simple route to spirolactam piperidines. Further synthetic work involving a challenging triazole cyclisation allowed the preparation of a spiropiperidine analogue of the eastern part of maraviroc. (C) 2010 Elsevier Ltd. All rights reserved.