bis(2,2,2-trichloroethyl) H-phosphonate | 72236-75-0

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: bis(2,2,2-trichloroethyl) H-phosphonate
• 英文别名: di-2,2,2-trichloroethyl H-phosphonate；phosphonic acid bis-(2,2,2-trichloro-ethyl) ester；phosphorous acid bis-(2,2,2-trichloro-ethyl) ester；1,1,1-Trichloro-2-[oxido(2,2,2-trichloroethoxy)phosphaniumyl]oxyethane
• CAS: 72236-75-0
• 化学式: C₄H₅Cl₆O₃P
• 分子量: 344.774
• InChiKey: HADBIZSOFJMAEJ-UHFFFAOYSA-N

物化性质

• 沸点：
  89-90 °C(Press: 0.05 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  41.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2,2-三氯乙醇 生成 bis(2,2,2-trichloroethyl) H-phosphonate
  参考文献：
  名称：

  BLIZNYUK, N. K.;BONDAREVA, T. A.;PROTASOVA, L. D.;BLIZNYUK, A. N.

  摘要：

  DOI：

文献信息

• [EN] AZIRIDINE CONTAINING EPOTHILONE ANALOGS, METHODS OF SYNTHESIS, METHODS OF TREATMENT, AND DRUG CONJUGATES<br/>[FR] ANALOGUES D'ÉPOTHILONE CONTENANT DE L'AZIRIDINE, PROCÉDÉS DE SYNTHÈSE, MÉTHODES DE TRAITEMENT, ET CONJUGUÉS MÉDICAMENTEUX DE CEUX-CI
  申请人：UNIV RICE WILLIAM M

  公开号：WO2018191394A1

  公开（公告）日：2018-10-18

  In one aspect, the present disclosure provides epothilone analogs of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

  在一个方面，本公开提供了公式为：(I)的紫杉醇类似物，其中变量如本文所定义。在另一个方面，本公开还提供了制备本文所披露化合物的方法。在另一个方面，本公开还提供了药物组合物和使用本文所披露化合物的方法。此外，还提供了具有细胞靶向基团的药物偶联物。
• Organophosphorus Chemistry without PCl₃: A Bridge from Hypophosphorous Acid to H-Phosphonate Diesters
  作者：Henry C. Fisher、Lucie Prost、Jean-Luc Montchamp

  DOI：10.1002/ejoc.201301412

  日期：2013.12

  A process for the conversion of hypophosphorous acid (H3PO2, HPA) and alcohols into various H-phosphonate diesters [(RO)2P(O)H] is described. The new reaction provides a missing bridge between HPA and important H-phosphonates, completely avoiding the use of PCl3. Nickel chloride or nickel on silica catalyze the oxidative phosphorylation of alkyl phosphinates with various alcohols or water. The reaction

  描述了将次磷酸 (H3PO2, HPA) 和醇转化为各种 H-膦酸二酯 [(RO)2P(O)H] 的过程。新反应在 HPA 和重要的 H-膦酸盐之间提供了一个缺失的桥梁，完全避免了 PCl3 的使用。氯化镍或二氧化硅上的镍催化烷基次膦酸盐与各种醇或水的氧化磷酸化。该反应是原子经济的，避免了废物的形成。完全避免了以前对氯和碱的需求。
• Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor
  申请人：Johnson A. David

  公开号：US20050107600A1

  公开（公告）日：2005-05-19

  This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.

  这项发明涉及生产烷基氨基葡糖氨磷酸化合物和二糖化合物的过程，包括各种新颖中间体和中间过程。在一个方面，通过将O-硅糖苷与二卤甲基烷醚反应来生产糖基卤化物。
• Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors and intermediates therefor
  申请人：——

  公开号：US20040267007A1

  公开（公告）日：2004-12-30

  This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.

  本发明涉及生产烷基氨基葡萄糖胺磷酸化合物和二糖化合物的过程，包括各种新的中间体和中间体过程。在一个方面，通过将O-硅基糖苷与二卤甲基烷醚反应来生产糖基卤化物。
• PROCESSES FOR THE PRODUCTION OF AMINOALKYL GLUCOSAMINIDE PHOSPHATE AND DISACCHARIDE IMMUNOEFFECTORS, AND INTERMEDIATES THEREFOR
  申请人：Johnson A. David

  公开号：US20080033155A1

  公开（公告）日：2008-02-07

  This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.

  本发明涉及生产烷基氨基葡糖氨磷酸化合物和二糖化合物的过程，包括各种新的中间体和中间过程。在一个方面，通过将O-硅糖苷与二卤甲基烷醚反应来产生糖基卤化物。