6-acetyl-1-oxaspiro[4.6]undeca-3,6-dien-2-one | 1456863-97-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-acetyl-1-oxaspiro[4.6]undeca-3,6-dien-2-one
• CAS: 1456863-97-0
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: UMQNCCNZGHPPGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.93
• 重原子数：
  15.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  6-acetyl-1-oxaspiro[4.6]undeca-3,6-dien-2-one 、 甲基锂 以 四氢呋喃 为溶剂， 反应 0.5h， 以93%的产率得到
  参考文献：
  名称：

  A general, flexible, ring closing metathesis (RCM) based strategy for accessing the fused furo[3,2-b]furanone moiety present in diverse bioactive natural products

  摘要：

  A simple and straightforward methodology of general utility to construct sterically encumbered furo[3,2-b]furanone scaffolds present in a diverse range of bioactive natural products is delineated. The methodology emanates from readily available Morita-Baylis-Hillman adducts and employs sequential ring closing metathesis and oxy-Michael addition cascade as the key steps. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.021
• 作为产物：
  描述：

  ((7-(allyloxy)-7-vinylcyclohept-1-en-1-yl)methoxy)(tert-butyl)diphenylsilane 在 Grubbs catalyst first generation 、 Jones reagent 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 为溶剂， 反应 13.0h， 生成 6-acetyl-1-oxaspiro[4.6]undeca-3,6-dien-2-one
  参考文献：
  名称：

  A general, flexible, ring closing metathesis (RCM) based strategy for accessing the fused furo[3,2-b]furanone moiety present in diverse bioactive natural products

  摘要：

  A simple and straightforward methodology of general utility to construct sterically encumbered furo[3,2-b]furanone scaffolds present in a diverse range of bioactive natural products is delineated. The methodology emanates from readily available Morita-Baylis-Hillman adducts and employs sequential ring closing metathesis and oxy-Michael addition cascade as the key steps. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.08.021