5-formyl-furan-2-carbothionic acid-S-2,4,6-trichlorophenyl ester | 685903-55-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚酯
• 英文名称: 5-formyl-furan-2-carbothionic acid-S-2,4,6-trichlorophenyl ester
• 英文别名: S-(2,4,6-trichlorophenyl) 5-formylfuran-2-carbothioate
• CAS: 685903-55-3
• 化学式: C₁₂H₅Cl₃O₃S
• 分子量: 335.595
• InChiKey: MVIGJFSIXDUHKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] 2 - SUBSTITUTED HETEROCYCLIC COMPOUNDS AND ANTITUMOR COMPOSITION COMPRISING THE SAME<br/>[FR] COMPOSES HETEROCYCLIQUES SUBSTITUES EN POSITION 2 ET COMPOSITION ANTITUMORALE RENFERMANT LESDITS COMPOSES
  申请人：CHONG KUN DANG PHARM CORP

  公开号：WO2004037808A1

  公开（公告）日：2004-05-06

  The present invention relates with 2-substituted heterocyclic compounds and antitumor composition comprising the same. The compound according to the present invention exhibits superior effect as telomerase inhibitor based on new mechanism (terlomere-terlomerase) which can resolve the problems occurring at the time of using chemotherapeutics, i.e side effects and cross resistance between related mechanism on using chemotherapeutics. In addition, the antitumor composition comprising the compound of the present invention exhibits superior effect in inhibiting the growth of cancer cell.

  本发明涉及2-取代杂环化合物和包括其在内的抗肿瘤组合物。根据本发明的化合物基于新机制（端粒酶-端粒酶）表现出优越的端粒酶抑制剂效果，可以解决在使用化疗药物时出现的问题，即副作用和化疗药物之间相关机制的交叉耐药性。此外，包括本发明化合物的抗肿瘤组合物表现出优越的抑制癌细胞生长的效果。