Phosphoric acid (E)-(R)-2-acetylamino-9-(2-hexadecyloxy-ethoxy)-non-3-enyl ester methyl ester | 223681-60-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: Phosphoric acid (E)-(R)-2-acetylamino-9-(2-hexadecyloxy-ethoxy)-non-3-enyl ester methyl ester
• CAS: 223681-60-5
• 化学式: C₃₀H₆₀NO₇P
• 分子量: 577.783
• InChiKey: GWJXHGDOGZROOO-SSEXGKCCSA-N

反应信息

• 作为反应物：
  描述：

  Phosphoric acid (E)-(R)-2-acetylamino-9-(2-hexadecyloxy-ethoxy)-non-3-enyl ester methyl ester 在 palladium on activated charcoal 甲酸 、 氢气 作用下， 以 甲醇 为溶剂， 生成 Phosphoric acid (R)-2-acetylamino-9-(2-hexadecyloxy-ethoxy)-nonyl ester methyl ester
  参考文献：
  名称：

  Synthesis and PLA2-inhibitory properties of 2(R)-acetamido-alkylphosphomethanols with a variable aggregate anchor

  摘要：

  Acylamino inhibitors of 14 kDa-PLA(2) were synthesized which differ in the moiety that is not bound into the enzyme's active site but immersed in the lipid aggregate when a ternary inhibitory complex is formed. Our results indicate that this part of the inhibitors does not significantly influence inhibitory properties as long the amphiphilic character is retained. So, inhibitory and biophysical properties should be variable independently. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00721-5
• 作为产物：
  描述：

  (E)-(R)-2-Amino-9-(2-hexadecyloxy-ethoxy)-non-3-en-1-ol 在 盐酸 、 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 、 氯仿 、 甲苯 为溶剂， 生成 Phosphoric acid (E)-(R)-2-acetylamino-9-(2-hexadecyloxy-ethoxy)-non-3-enyl ester methyl ester
  参考文献：
  名称：

  Synthesis and PLA2-inhibitory properties of 2(R)-acetamido-alkylphosphomethanols with a variable aggregate anchor

  摘要：

  Acylamino inhibitors of 14 kDa-PLA(2) were synthesized which differ in the moiety that is not bound into the enzyme's active site but immersed in the lipid aggregate when a ternary inhibitory complex is formed. Our results indicate that this part of the inhibitors does not significantly influence inhibitory properties as long the amphiphilic character is retained. So, inhibitory and biophysical properties should be variable independently. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00721-5