(S)-4-(2-amino-3-(tert-butoxy)-3-oxopropyl)phenyl 4-(heptyloxy)benzoate | 1352293-18-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: (S)-4-(2-amino-3-(tert-butoxy)-3-oxopropyl)phenyl 4-(heptyloxy)benzoate
• 英文别名: [4-[(2S)-2-amino-3-[(2-methylpropan-2-yl)oxy]-3-oxopropyl]phenyl] 4-heptoxybenzoate
• CAS: 1352293-18-5
• 化学式: C₂₇H₃₇NO₅
• 分子量: 455.594
• InChiKey: BKVAEADDYMLHLI-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  33
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  87.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS
  申请人：Boehm Marcus F.

  公开号：US20110306542A1

  公开（公告）日：2011-12-15

  Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.

  提供结合胰高血糖素样肽1受体（GLP-1）受体的化合物，包括调节GLP-1受体的化合物和能够诱导受体稳定作用的化合物，用于结构分析GLP-1受体。提供合成方法、治疗和/或预防性使用方法，以及在体外稳定GLP-1受体以结晶GLP-1受体的方法。
• US8501982B2
  申请人：——

  公开号：US8501982B2

  公开（公告）日：2013-08-06
• US8816121B2
  申请人：——

  公开号：US8816121B2

  公开（公告）日：2014-08-26
• [EN] NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS<br/>[FR] NOUVEAUX STABILISANTS ET MODULATEURS DE RÉCEPTEUR GLP-1
  申请人：RECEPTOS INC

  公开号：WO2011156655A2

  公开（公告）日：2011-12-15

  Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.