6-(4-fluoro-piperidin-1-ylmethyl)-2-(1H-pyrrol-2-yl)thieno[2,3-d]pyrimidin-4-ylamine | 1221434-39-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 6-(4-fluoro-piperidin-1-ylmethyl)-2-(1H-pyrrol-2-yl)thieno[2,3-d]pyrimidin-4-ylamine
• 英文别名: 6-[(4-fluoropiperidin-1-yl)methyl]-2-(1H-pyrrol-2-yl)thieno[2,3-d]pyrimidin-4-amine
• CAS: 1221434-39-4
• 化学式: C₁₆H₁₈FN₅S
• 分子量: 331.417
• InChiKey: DIEDWCRKPJYZJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  99.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] METHYLENE AMINES OF THIENO [2,3-D] PYRIMIDINE AND THEIR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS<br/>[FR] AMINES MÉTHYLÉNIQUES DE THIÉNO [2,3-D] PYRIMIDINE ET LEUR UTILISATION COMME ANTAGONISTES DES RÉCEPTEURS DE L'ADÉNOSINE A2A
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010045006A1

  公开（公告）日：2010-04-22

  This invention relates to a novel thieno[2,3-d]pyrimidine, A, and its therapeutic and prophylactic uses, wherein R1 and R2 are definedin the specification. Disorders treated and/or prevented include Parkinson's Disease.

  这项发明涉及一种新型噻吩[2,3-d]嘧啶A及其治疗和预防用途，其中R1和R2在规范中有定义。治疗和/或预防的疾病包括帕金森病。
• METHYLENE AMINES OF THIENO[2,3-d]PYRIMIDINE AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS
  申请人：Barbay J. Kent

  公开号：US20100093702A1

  公开（公告）日：2010-04-15

  This invention relates to a novel thieno[2,3-d]pyrimidine, A, and its therapeutic and prophylactic uses, wherein R 1 and R 2 are defined in the specification. Disorders treated and/or prevented include Parkinson's Disease.

  本发明涉及一种新型噻吩[2,3-d]嘧啶A及其治疗和预防用途，其中R1和R2在说明书中有定义。治疗和/或预防的疾病包括帕金森病。
• Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
  申请人：SHY Therapeutics LLC

  公开号：US10588894B2

  公开（公告）日：2020-03-17

  Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

  本文提供了通过化合物与 Ras 超家族蛋白（在某些情况下包括 K-Ras 及其突变体）的 GTP 结合结构域结合，治疗涉及 Ras 超家族信号异常的癌症、炎症性疾病、rasopathies 和纤维化疾病的方法和组合物，以及检测此类组合物的新方法。
• METHYLENE AMINES OF THIENO Ý2,3-D¨PYRIMIDINE AND THEIR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2350092A1

  公开（公告）日：2011-08-03
• COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE
  申请人：SHY Therapeutics LLC

  公开号：US20190022074A1

  公开（公告）日：2019-01-24

  Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.