| 1253405-10-5

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• CAS: 1253405-10-5
• 化学式: C₂₇H₄₁N₃O₄
• 分子量: 471.64
• InChiKey: QQLKZXYUSYXLNV-ABEABDQWSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2

  摘要：

  Further structure activity relationship studies on a previously reported 8-azabicyclo[3.2.1]octan-3-yloxy-benzamide series of potent and selective kappa opioid receptor antagonists is discussed. Modification of the pendant N-substitution to include a cyclohexylurea moiety produced analogs with greater in vitro opioid and hERG selectivity such as 12 (kappa IC50 = 172 nM, mu:kappa ratio = 93, delta:kappa ratio = >174, hERG IC50 = >33 mu M). Changes to the linker conformation and identity as well as to the benzamide ring moiety were also investigated. (c) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.07.112
• 作为产物：
  描述：

  、 TERT-BUTYL TRANS-4-(2-OXOETHYL)CYCLOHEXYLCARBAMATE 在 macroporous polystyrene bound triacetoxyborohydride 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2

  摘要：

  Further structure activity relationship studies on a previously reported 8-azabicyclo[3.2.1]octan-3-yloxy-benzamide series of potent and selective kappa opioid receptor antagonists is discussed. Modification of the pendant N-substitution to include a cyclohexylurea moiety produced analogs with greater in vitro opioid and hERG selectivity such as 12 (kappa IC50 = 172 nM, mu:kappa ratio = 93, delta:kappa ratio = >174, hERG IC50 = >33 mu M). Changes to the linker conformation and identity as well as to the benzamide ring moiety were also investigated. (c) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2010.07.112