methyl dipropylcarbamodithioate | 52041-13-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 二硫代氨基甲酸及其衍生物
• 英文名称: methyl dipropylcarbamodithioate
• 英文别名: dipropyl-dithiocarbamic acid methyl ester；Dipropyl-dithiocarbamidsaeure-methylester；N.N-Dipropyl-dithiourethylan；methyl N,N-dipropylcarbamodithioate
• CAS: 52041-13-1
• 化学式: C₈H₁₇NS₂
• 分子量: 191.362
• InChiKey: ZDUMFHBOYMJZBR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  60.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  二正丙胺 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 15.0h， 生成 methyl dipropylcarbamodithioate
  参考文献：
  名称：

  二烷基二硫代氨基甲酸甲酯在润滑组合物中的摩擦学性能

  摘要：

  摘要 通过仲胺、氢氧化钠和二硫化碳之间的反应，然后将甲基碘引入反应混合物，我们合成并表征了许多含有正烷基和异烷基（C 2 -C 5 ）的二烷基二硫代氨基甲酸甲酯。 ）。当合成的化合物添加到合成润滑剂中时，获得了摩擦学性能数据。添加剂被证明显着改善了所得润滑组合物的抗磨损、抗咬合和抗摩擦性能。研究了酯的浓度和结构对润滑剂摩擦磨损参数的影响。

  DOI：

  10.1134/s0965544122040132

文献信息

• Exploring the Structural Requirements for Inhibition of the Ubiquitin E3 Ligase Breast Cancer Associated Protein 2 (BCA2) as a Treatment for Breast Cancer
  作者：Ghali Brahemi、Fathima R. Kona、Annalisa Fiasella、Daniela Buac、Jitka Soukupová、Andrea Brancale、Angelika M. Burger、Andrew D. Westwell

  DOI：10.1021/jm901757t

  日期：2010.4.8

  The zinc-ejecting aldehyde dehydrogenase (A LDH) inhibitory drug disulfiram (DS F) was found to be a breast cancer-associated protein 2 (BCA2) inhibitor with potent antitumor activity. We herein describe our work in the synthesis and evaluation of new series of zinc-affinic molecules to explore the structural requirements for selective BCA2-inhibitory antitumor activity. An N(C=S)S-S motif was found to be required, based on selective activity in BCA2-expressing breast cancer cell lines and against recombinant BCA2 protein. Notably, the DSF analogs (3a and 3c) and dithio(peroxo)thioate compounds (5d and 5f) were found to have potent activity (submicromolar IC(50)) in BCA2 positive MCF-7 and T47D cells but were inactive (IC(50)> 10 mu M) in BCA2 negative M DA-MB-231 breast cancer cells and the normal breast epithelial cell line MCF10A. Testing in the isogenic BCA2 +ve M DA-MB-231/ER cell line restored antitumor activity for compounds that were inactive in the BCA2 -ve MDA-MB-231 cell line. In contrast, structurally related dithiocarbamates and benzisothiazolones (lacking the disulfide bond) were all inactive. Compounds 5d and 5f were additionally found to lack ALDH-inhibitory activity, suggestive of selective E3 ligase-inhibitory activity and worthy of further development.
• Delepine, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1902, vol. 134, p. 715
  作者：Delepine

  DOI：——

  日期：——
• Tribological Performance of Dialkyldithiocarbamic Acid Methyl Esters in Lubricating Compositions
  作者：E. Yu. Oganesova、E. G. Bordubanova、A. S. Lyadov、O. P. Parenago

  DOI：10.1134/s0965544122040132

  日期：2022.6

  of dialkyldithiocarbamic acid methyl esters that contained n-alkyl and iso-alkyl groups (C2–C5). Tribological performance data were obtained for the compounds synthesized as they were added to synthetic lubricants. The additives were demonstrated to markedly improve the antiwear, antiseizure, and antifriction properties of the resultant lubricating compositions. The effects of the concentration and

  摘要 通过仲胺、氢氧化钠和二硫化碳之间的反应，然后将甲基碘引入反应混合物，我们合成并表征了许多含有正烷基和异烷基（C 2 -C 5 ）的二烷基二硫代氨基甲酸甲酯。 ）。当合成的化合物添加到合成润滑剂中时，获得了摩擦学性能数据。添加剂被证明显着改善了所得润滑组合物的抗磨损、抗咬合和抗摩擦性能。研究了酯的浓度和结构对润滑剂摩擦磨损参数的影响。