| 1231901-50-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• CAS: 1231901-50-0
• 化学式: C₂₁H₄₃O₉PS
• 分子量: 502.607
• InChiKey: YJJGXHFFLXVTEO-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 sodium methylate 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以100%的产率得到
  参考文献：
  名称：

  Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents

  摘要：

  Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on similar to 2 nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.079
• 作为产物：
  描述：

  C₂₁H₄₁Cl₂O₇PS 在 水 作用下， 以 1,3-二噁烷 为溶剂， 反应 12.0h， 以231 mg的产率得到
  参考文献：
  名称：

  Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents

  摘要：

  Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on similar to 2 nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.079