5-(2-fluoropyridin-3-yl)-1-[3-[3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]-4,5,6,7-tetrahydro-2H-indazol-3-one | 1022144-51-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: 5-(2-fluoropyridin-3-yl)-1-[3-[3-(5-fluoropyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]-4,5,6,7-tetrahydro-2H-indazol-3-one
• CAS: 1022144-51-9
• 化学式: C₂₂H₁₈F₂N₆O₃
• 分子量: 452.42
• InChiKey: KYAUYRWCWANWJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
  申请人：Beresis Richard T.

  公开号：US20100204278A1

  公开（公告）日：2010-08-12

  The present invention encompasses compounds of Formula (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.

  本发明涵盖了公式（I）的化合物，以及其药学上可接受的盐和水合物，可用于治疗动脉粥样硬化，血脂异常等。还包括制药组合物和使用方法。
• [EN] NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT<br/>[FR] AGONISTES DE RÉCEPTEUR DE NIACINE, COMPOSITIONS CONTENANT CES COMPOSES ET PROCÉDÉS DE TRAITEMENT
  申请人：MERCK & CO INC

  公开号：WO2008051403A2

  公开（公告）日：2008-05-02

  [EN] The present invention encompasses compounds of Formula (I) as well as pharmaceutically acceptable salts and hydrates thereof, that are useful for treating atherosclerosis, dyslipidemias and the like. Pharmaceutical compositions and methods of use are also included.
  [FR] L'invention concerne des composes de la formule (I) ainsi que des sels et des hydrates pharmaceutiquement acceptables de ceux-ci, lesquels sont utiles dans le traitement de l'athérosclérose, des dyslipidémies et analogue. L'invention concerne également des compositions pharmaceutiques et des procédés.