2'-O-甲基鸟苷5'-单磷酸酯 | 24121-01-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 中文名称: 2'-O-甲基鸟苷5'-单磷酸酯
• 中文别名: 1H-苯并咪唑,2-(乙炔基硫代)-；2'-甲氧基-鸟苷单磷酸；2'-甲氧基鸟苷单磷酸二钠
• 英文名称: 2'-O-Methylguanosine 5'-monophosphate
• 英文别名: [(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxy-4-methoxyoxolan-2-yl]methyl dihydrogen phosphate
• CAS: 24121-01-5
• 化学式: C₁₁H₁₆N₅O₈P
• 分子量: 377.25
• InChiKey: YPMKZCOIEXUDSS-KQYNXXCUSA-N

物化性质

• 密度：
  2.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  191
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Compositions and methods for inhibiting expression of Nav1.8 gene
  申请人：Sah Dinah

  公开号：US20070105806A1

  公开（公告）日：2007-05-10

  The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Nav1.8 gene (Nav1.8 gene), comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of the Nav1.8 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the Nav1.8 gene using the pharmaceutical composition; and methods for inhibiting the expression of the Nav1.8 gene gene in a cell.

  该发明涉及一种双链核糖核酸(dsRNA)，用于抑制Nav1.8基因(Nav1.8基因)的表达，包括具有核苷酸序列的反义链，其长度小于25个核苷酸，并且与Nav1.8基因的至少一部分基本互补。该发明还涉及包括dsRNA和药用可接受载体的药物组合物；使用该药物组合物治疗由Nav1.8基因表达引起的疾病的方法；以及在细胞中抑制Nav1.8基因表达的方法。
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE EBOLA
  申请人：Bavari Sina

  公开号：US20090143323A1

  公开（公告）日：2009-06-04

  The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a gene from the Ebola virus.

  这项发明涉及一种用于抑制埃博拉病毒基因表达的双链核糖核酸(dsRNA)。
• Compositions and methods for inhibiting expression of huntingtin gene
  申请人：Sah Wen-Yee Dinah

  公开号：US20070099860A1

  公开（公告）日：2007-05-03

  The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Huntingtin gene (HD gene), comprising an antisense strand having a nucleotide sequence which is less than 25 nucleotides in length and which is substantially complementary to at least a part of the HD gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of the HD gene, or a mutant form thereof, using the pharmaceutical composition; and methods for inhibiting the expression of the huntingtin gene in a cell.

  该发明涉及一种双链核糖核酸(dsRNA)，用于抑制Huntingtin基因(HD基因)的表达，包括具有核苷酸序列的反义链，其长度小于25个核苷酸，并且与HD基因的至少一部分基本互补。该发明还涉及包括dsRNA和药用载体的药物组合物；使用该药物组合物治疗由HD基因的表达或其突变形式引起的疾病的方法；以及在细胞中抑制huntingtin基因表达的方法。
• Lipid Formulated Compositions and Methods for Inhibiting Expression of Serum Amyloid A Gene
  申请人：de Fougerolles Antonin

  公开号：US20110263684A1

  公开（公告）日：2011-10-27

  The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a Serum Amyloid A (SAA) gene, and methods of using the dsRNA to inhibit expression of SAA.

  这项发明涉及一种针对血清淀粉样蛋白A（SAA）基因的双链核糖核酸（dsRNA），以及使用该dsRNA抑制SAA表达的方法。
• Compositions And Methods For Inhibiting Expression Of GSK-3 Genes
  申请人：Sah Dinah Wen-Yee

  公开号：US20110184046A1

  公开（公告）日：2011-07-28

  The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods of using the dsRNA to inhibit expression of GSK-3.

  这项发明涉及一种靶向糖原合成酶激酶-3（GSK-3）的双链核糖核酸（dsRNA），以及使用该dsRNA抑制GSK-3表达的方法。