3,3-dimethyl-5,5-pentamethylene-morpholine | 90017-29-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 3,3-dimethyl-5,5-pentamethylene-morpholine
• 英文别名: 2,2-Dimethyl-4-oxa-1-azaspiro[5.5]undecane
• CAS: 90017-29-1
• 化学式: C₁₁H₂₁NO
• mdl: MFCD09722925
• 分子量: 183.294
• InChiKey: NQSIEXOTNWXEBC-UHFFFAOYSA-N

物化性质

• 沸点：
  102-105 °C(Press: 9 Torr)
• 密度：
  0.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  sodium 2-[2-methyl-1-hydroxy-2-propylamino]-2-cyclohexyl carboxylate 在 盐酸 、 lithium aluminium tetrahydride 、 甲烷磺酸 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 44.0h， 生成 3,3-dimethyl-5,5-pentamethylene-morpholine
  参考文献：
  名称：

  Hindered Amines¹. 3,3,5,5-Tetrasubstituted-2-oxomorpholines and Derivatives

  摘要：

  DOI：

  10.1055/s-1984-30746

文献信息

• Polysubstituted 2-morpholones, related compounds, processes for their
  申请人：The B. F. Goodrich Company

  公开号：US04914232A1

  公开（公告）日：1990-04-03

  An essentially single stage reaction has been discovered in which a disubstituted ethanolamine, that is, a 2,2'-substituted-2-aminoethanol, may be reacted with a haloform and a carbonyl containing compound selected from the group consisting of monoketones and benzaldehyde, in the presence of an alkali metal hydroxide, and optionally in the presence of a phase transfer catalyst, to produce an alkali metal hydroxyethylaminoacetate ("HEAA") which has N-adjacent C atoms on which there are a total of at least three substituents (hence "polysubstituted"), and one or both pairs of substituents on each N-adjacent C atom may be cyclized. The HEAA may be cyclized by the action of a mineral acid to produce a 2-morpholone hydrochloride which is characterized by having a total of at least three substituents on the N-adjacent C atoms of the ring. The 2-morpholone so produced may be reduced to a polysubstituted aminodiol. The aminodiol so produced may be cyclized with an alkane sulfonic acid to yield a polysubstituted morpholine which could not otherwise have been made. The aminodiol may also be alkylated to produce diethers with polysubstituted N-adjacent C atoms. If the aminodiol is tosylated, a polysubstituted crown ether is produced with plural polyalkylene groups. The foregoing HEAA and related compounds are used as u-v light stabilizers in novel compositions in which a small but effective amount of one or more of the HEAA and related compounds is incorporated, in an amount sufficient to produce desirable stabilization against degradation by u-v light in a wide variety of organic materials.

  发现了一种基本上的单步反应，其中二取代的乙醇胺，即2,2'-取代的-2-氨基乙醇，可以与卤仿和选自单酮和苯甲醛的含羰基化合物在碱金属氢氧化物存在下反应，并可选择性地在相转移催化剂存在下反应，以产生具有N-相邻C原子上的至少三个取代基（因此称为“多取代”）的碱金属羟乙基氨基乙酸酯（“HEAA”），并且每个N-相邻C原子上的一个或两个取代基对可以环化。HEAA可以通过无机酸的作用环化，产生具有环的N-相邻C原子上的至少三个取代基的2-吗啉酮盐酸盐。产生的2-吗啉酮可以被还原为多取代的氨基二醇。产生的氨基二醇可以通过与烷基磺酸反应环化，产生不能通过其他方式制备的多取代吗啉。氨基二醇也可以被烷基化，产生具有多取代N-相邻C原子的二醚。如果氨基二醇被对甲苯磺酰化，会产生具有多个聚亚烷基基团的多取代冠醚。上述HEAA及其相关化合物被用作新型组合物中的紫外线稳定剂，其中包含一种或多种HEAA及其相关化合物的小而有效的量，足以在各种有机材料中产生对抗紫外线降解的理想稳定性。
• Polysubstituted 2-morpholones
  申请人：——

  公开号：US04528370A1

  公开（公告）日：1985-07-09

  An essentially single stage reaction has been discovered in which a disubstituted ethanolamine, that is, a 2,2'-substituted-2-aminoethanol, may be reacted with a haloform and a carbonyl containing compound selected from the group consisting of monoketones and benzaldehyde, in the presence of an alkali metal hydroxide, and optionally in the presence of a phase transfer catalyst, to produce an alkali metal hydroxyethylaminoacetate ("HEAA") which has N-adjacent C atoms on which there are a total of at least three substituents (hence "polysubstituted"), and one or both pairs of substituents on each N-adjacent C atom may be cyclized. The HEAA may be cyclized by the action of a mineral acid to produce a 2-morpholone hydrochloride which is characterized by having a total of at least three substituents on the N-adjacent C atoms of the ring. The 2-morpholone so produced may be reduced to a polysubstituted aminodiol. The aminodiol so produced may be cyclized with an alkane sulfonic acid to yield a polysubstituted morpholine which could not otherwise have been made. The aminodiol may also be alkylated to produce diethers with polysubstituted N-adjacent C atoms. If the aminodiol is tosylated, a polysubstituted crown ether is produced with plural polyalkylene groups. The foregoing HEAA and related compounds are used as u-v light stabilizers in novel compositions in which a small but effective amount of one or more of the HEAA and related compounds is incorporated, in an amount sufficient to produce desirable stabilization against degradation by u-v light in a wide variety of organic materials.

  发现了一种实质上的单级反应，其中二取代乙醇胺，即2,2'-取代-2-氨基乙醇，可以在碱金属氢氧化物存在下，并可选择性地在相转移催化剂存在下，与卤仿和选自单酮和苯甲醛的含羰基化合物反应，生成碱金属羟乙基氨基乙酸酯("HEAA")，其在N-相邻的C原子上具有总数至少三个取代基(因此称为"多取代")，并且每个N-相邻C原子上的一个或两个取代基对可以环化。HEAA可以通过无机酸的作用环化生成2-吗啉酮盐酸盐，其特征在于环的N-相邻C原子上具有总数至少三个取代基。由此产生的2-吗啉酮可以被还原成多取代氨基二醇。由此产生的氨基二醇可以通过与烷烃磺酸反应环化生成原本无法制备的多取代吗啉。氨基二醇也可以被烷基化以产生具有多取代N-相邻C原子的二醚。如果氨基二醇被对甲苯磺酰化，会产生具有多个聚亚烷基的多取代冠醚。上述HEAA及其相关化合物被用作新颖组合物中的紫外线稳定剂，其中包含少量但有效的HEAA及其相关化合物，足以在各种有机材料中产生对紫外线降解的理想稳定作用。
• LAI, J. T., SYNTHESIS, BRD, 1984, N 2, 122-123
  作者：LAI, J. T.

  DOI：——

  日期：——
• N-OXYL-RADIKALE
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1204648A1

  公开（公告）日：2002-05-15
• US4528370A
  申请人：——

  公开号：US4528370A

  公开（公告）日：1985-07-09