N-cyclopropyl-2-(3-(5-((2-fluoro-4-iodophenyl)amino)-3,6,8-trimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide | 1456714-03-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: N-cyclopropyl-2-(3-(5-((2-fluoro-4-iodophenyl)amino)-3,6,8-trimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide
• 英文别名: N-cyclopropyl-2-[3-[5-(2-fluoro-4-iodoanilino)-3,6,8-trimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1-yl]phenyl]acetamide
• CAS: 1456714-03-6
• 化学式: C₂₇H₂₅FIN₅O₄
• 分子量: 629.43
• InChiKey: NXDRXCJNYYLHQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLYLE EN TANT QU'INHIBITEURS DE MEK
  申请人：LUPIN LTD

  公开号：WO2013136249A1

  公开（公告）日：2013-09-19

  The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of Formula (I), their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below:

  本公开涉及杂环芳基化合物作为MEK抑制剂。这些化合物包括公式(I)的杂环芳基化合物，它们的药用盐，与适当药物的组合以及其制剂。本公开还包括这些化合物的制备方法和它们在治疗方法中的应用。本公开所披露的化合物如下所示：
• HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
  申请人：LUPIN LIMITED

  公开号：US20150133424A1

  公开（公告）日：2015-05-14

  The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of formula I, their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereof. The present disclosure also includes processes of preparation of the compounds and their use in methods of treatment. The compounds as disclosed herein are of Formula (I) below:

  本公开涉及杂环芳基化合物作为MEK抑制剂。这些化合物包括式I的杂环芳基化合物，它们的药用盐，与合适药物的组合以及其制剂。本公开还包括所述化合物的制备方法和它们在治疗方法中的应用。所述化合物的化学式如下：
• [EN] ANTICANCER COMBINATION THERAPY<br/>[FR] POLYTHÉRAPIE ANTICANCÉREUSE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2020254451A1

  公开（公告）日：2020-12-24

  The invention describes anti-cancer therapies comprising using a SOS1 inhibitor in combination with a MEK inhibitor, each as described herein.

  这项发明描述了抗癌疗法，包括使用SOS1抑制剂与MEK抑制剂的组合，如本文所述。
• US9428499B2
  申请人：——

  公开号：US9428499B2

  公开（公告）日：2016-08-30
• US9555035B2
  申请人：——

  公开号：US9555035B2

  公开（公告）日：2017-01-31