(E)-(3,4-difluorophenyl)(5-{[6-(7-quinazolinyl)-2,6-diazaspiro[3.3]hept-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime | 1202178-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: (E)-(3,4-difluorophenyl)(5-{[6-(7-quinazolinyl)-2,6-diazaspiro[3.3]hept-2-yl]methyl}-2-pyridinyl)methanone O-ethyloxime
• 英文别名: (E)-1-(3,4-difluorophenyl)-N-ethoxy-1-[5-[(2-quinazolin-7-yl-2,6-diazaspiro[3.3]heptan-6-yl)methyl]pyridin-2-yl]methanimine
• CAS: 1202178-60-6
• 化学式: C₂₈H₂₆F₂N₆O
• 分子量: 500.551
• InChiKey: FBVWHJQJVFNANV-DNGXXSEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.7
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE
  申请人：Ando Makoto

  公开号：US20110071129A1

  公开（公告）日：2011-03-24

  [Problem] To provide a melanin concentrating hormone receptor antagonist useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders. [Means for Resolution] Provided are compound of a formula (I): [wherein R 1 a and R 1 b each are a hydrogen atom, etc.; R 2 is a hydrogen atom, a C 1-6 alkyl, etc.; Ar 1 is a 6-membered aromatic carbocyclic group or a 6-membered aromatic nitrogen-containing heterocyclic group; Ar 2 is a group to be formed by removing two hydrogen atoms from a 6-membered aromatic carbon ring, a 6-membered aromatic nitrogen-containing hetero ring, etc.; Ar 3 is a mono- or bi-cyclic aromatic carbon ring or aromatic hetero ring; m 1 , m 2 , m 3 and m 4 each are independently 0, 1, 2, 3 or 4, provided that the total of m 1 and m 2 is from 2 to 6, the total of m 3 and m 4 is from 2 to 6]. The compounds are useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders.

  [问题] 提供一种黑色素浓集激素受体拮抗剂，可用作中枢系统疾病、心血管疾病和代谢性疾病的药物。[解决方案] 提供了一种公式（I）的化合物：[其中R1a和R1b分别是氢原子等；R2是氢原子、C1-6烷基等；Ar1是6元芳香碳环基或6元芳香氮杂环基；Ar2是从6元芳香碳环、6元芳香氮杂环等中去除两个氢原子形成的基团；Ar3是单环或双环芳香碳环或芳香杂环；m1、m2、m3和m4各自独立地为0、1、2、3或4，前提是m1和m2的总和为2到6，m3和m4的总和为2到6]。这些化合物可用作中枢系统疾病、心血管疾病和代谢性疾病的药物。
• EP2301936A1
  申请人：——

  公开号：EP2301936A1

  公开（公告）日：2011-03-30