dimethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5,6-dicarboxylate | 811442-59-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吖庚因类
• 英文名称: dimethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5,6-dicarboxylate
• CAS: 811442-59-8
• 化学式: C₁₆H₁₈N₂O₄
• 分子量: 302.33
• InChiKey: BAQGJWPEPDVFGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  68.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dimethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5,6-dicarboxylate 以12%的产率得到
  参考文献：
  名称：

  Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones

  摘要：

  Reaction of 3-(1-alkylamino)pyridines with electron deficient acetylenes in the presence of acids yields 1,2-dihydro-[2,7]naphthyridine-3,4-dialkyldicarboxylates 4 in 35-72% yield. Compounds 4 unsubstituted in position 1 can be easily oxidized with potassium permanganate into the respective naphthyridine-1-ones derivatives 5 in good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.053
• 作为产物：
  描述：

  以 乙醇 为溶剂， 反应 12.33h， 生成 dimethyl 9,10,11,11a-tetrahydro-8H-pyrido[2,1-a][2,7]naphthyridine-5,6-dicarboxylate
  参考文献：
  名称：

  Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones

  摘要：

  Reaction of 3-(1-alkylamino)pyridines with electron deficient acetylenes in the presence of acids yields 1,2-dihydro-[2,7]naphthyridine-3,4-dialkyldicarboxylates 4 in 35-72% yield. Compounds 4 unsubstituted in position 1 can be easily oxidized with potassium permanganate into the respective naphthyridine-1-ones derivatives 5 in good yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.04.053