Salicylsaeure-(2-acetamido-phenylester) | 20978-59-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: Salicylsaeure-(2-acetamido-phenylester)
• 英文别名: (2-Acetamidophenyl) 2-hydroxybenzoate
• CAS: 20978-59-0
• 化学式: C₁₅H₁₃NO₄
• 分子量: 271.273
• InChiKey: AAPRKNGDVXLHEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] FORMULATIONS<br/>[FR] FORMULATIONS
  申请人：SYNTOPIX GROUP PLC

  公开号：WO2011001165A2

  公开（公告）日：2011-01-06

  Anti-acne formulation containing (i) 3.5% w/v or greater of a dialkyl sulpho succinate (DAS) such as a dioctyl sulpho succinate and (ii) salicylic acid or a derivative thereof (other than a halogenated salicylanilide), which is suitable for application as a topical leave-on formulation. The salicylic acid or derivative may be present at a concentration of 0.5% w/w. The formulation may contain, in addition to the DAS and the salicylic acid or derivative, (a) a polyoxyalkylene-based solubilising agent and (b) an organic solvent, in particular an alcohol, optionally together with a thickening agent and/or water. It may contain an antioxidant such as AO 2246 or AO 425. It may be applied once daily over a period of several weeks.