5-(2,4-difluorophenyl)-6,7-dihydro-2-[(3-methylphenyl)methoxy]-thiazolo[5,4-c]pyridin-4(5H)-one | 1312414-41-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 5-(2,4-difluorophenyl)-6,7-dihydro-2-[(3-methylphenyl)methoxy]-thiazolo[5,4-c]pyridin-4(5H)-one
• 英文别名: 5-(2,4-Difluorophenyl)-2-[(3-methylphenyl)methoxy]-6,7-dihydro-[1,3]thiazolo[5,4-c]pyridin-4-one
• CAS: 1312414-41-7
• 化学式: C₂₀H₁₆F₂N₂O₂S
• 分子量: 386.422
• InChiKey: YGDWCVUJCJHOJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  70.7
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS<br/>[FR] THIAZOLES BICYCLIQUES EN TANT QUE MODULATEURS ALLOSTÉRIQUES DES RÉCEPTEURS MGLUR5
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2011073339A1

  公开（公告）日：2011-06-23

  The present invention relates to novel bicyclic thiazoles of formula (I) which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 ("mGluR5") and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved.

  本发明涉及具有式(I)的新型双环噻唑，它们是代谢型谷氨酸受体亚型5（"mGluR5"）的阳性变构调节剂，可用于治疗或预防与谷氨酸功能障碍有关的疾病以及涉及mGluR5亚型受体的疾病。该发明还涉及包含这些化合物的药物组合物，用于制备这些化合物和组合物的方法，以及用于预防和治疗涉及mGluR5的疾病的这些化合物和组合物的用途。
• BICYCLIC THIAZOLES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2513117A1

  公开（公告）日：2012-10-24
• US9040707B2
  申请人：——

  公开号：US9040707B2

  公开（公告）日：2015-05-26