acetic acid 2-{2-[5-chloro-4-((1R,2R)-2-methanesulfonylamino-cyclohexylamino)-pyrimidin-2-ylamino]-6,7-dihydro-9H-5-thia-8-aza-benzocyclohepten-8-yl}-ethyl ester | 1022974-46-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: acetic acid 2-{2-[5-chloro-4-((1R,2R)-2-methanesulfonylamino-cyclohexylamino)-pyrimidin-2-ylamino]-6,7-dihydro-9H-5-thia-8-aza-benzocyclohepten-8-yl}-ethyl ester
• 英文别名: 2-[7-[[5-chloro-4-[[(1R,2R)-2-(methanesulfonamido)cyclohexyl]amino]pyrimidin-2-yl]amino]-3,5-dihydro-2H-1,4-benzothiazepin-4-yl]ethyl acetate
• CAS: 1022974-46-4
• 化学式: C₂₄H₃₃ClN₆O₄S₂
• 分子量: 569.149
• InChiKey: BDMKTCHXHOZNHJ-NHCUHLMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  159
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND c-MET INHIBITORS
  申请人：Ahmed Gulzar

  公开号：US20090221555A1

  公开（公告）日：2009-09-03

  The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

  本发明提供公式I或II化合物或其药学上可接受的盐形式，其中R1、R2、R3、R4、R5、A1、A2、A3、A4和A5如本文所定义。公式I或II化合物具有ALK和/或c-Met抑制活性，可用于治疗增殖性疾病。
• Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors
  申请人：Ahmed Gulzar

  公开号：US20120165519A1

  公开（公告）日：2012-06-28

  The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.

  本发明提供了式I或II的化合物或其药学上可接受的盐形式，其中R1、R2、R3、R4、R5、A1、A2、A3、A4和A5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，并可用于治疗增生性疾病。
• FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS
  申请人：Cephalon, Inc.

  公开号：EP2222647B1

  公开（公告）日：2015-08-05
• Fused bicyclic derivatives of 2,4-diaminopyrimidine as alk and C-met inhibitors
  申请人：Cephalon, Inc.

  公开号：EP2684874B1

  公开（公告）日：2017-05-17
• US8148391B2
  申请人：——

  公开号：US8148391B2

  公开（公告）日：2012-04-03