3,6,8-Trihydroxy-3-methyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione | 155748-62-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 角环素
• 英文名称: 3,6,8-Trihydroxy-3-methyl-2,4-dihydrobenzo[a]anthracene-1,7,12-trione
• CAS: 155748-62-2
• 化学式: C₁₉H₁₄O₆
• 分子量: 338.3
• InChiKey: JJOLHRYZQSDLSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] SYNTHESIS OF NOVEL ASYMMETRIC BOW-TIE PAMAM DENDRIMER-BASED CONJUGATES FOR TUMOR-TARGETING DRUG DELIVERY<br/>[FR] SYNTHÈSE DE NOUVEAUX CONJUGUÉS ASYMÉTRIQUES À BASE D'UN DENDRIMÈRE PAMAM EN NŒUD PAPILLON POUR ADMINISTRATION DE MÉDICAMENTS CIBLÉE VERS UNE TUMEUR
  申请人：UNIV NEW YORK STATE RES FOUND

  公开号：WO2015038493A1

  公开（公告）日：2015-03-19

  The present disclosure relates to a dendrimer-based conjugate of the formula Vm-D-C-D'-(T-F)n, which is useful for tumor targeting drug delivery. The use of asymmetric dendrimers allow for specific targeting as well as synthetic reproducibility.

  本公开涉及一种公式为Vm-D-C-D'-(T-F)n的基于树状聚合物的结合物，该结合物对于肿瘤靶向药物传递很有用。不对称树状聚合物的使用可以实现特定的靶向以及合成的可重复性。
• OVIEDOMYCIN DERIVATIVES, METHOD FOR OBTAINING SAME AND USE THEREOF
  申请人：Universidad De Oviedo

  公开号：EP2269972A1

  公开（公告）日：2011-01-05

  Oviedomycin derivatives, method for obtaining same and use thereof. This invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to produce the oviedomycin derivatives. The invention further relates to bacterial strains that can be used to produce oviedomycin derivatives. Finally, said oviedomycin derivatives are applicable in the field of the human health, specifically to produce drugs for the treatment of tumour diseases.

  卵霉素衍生物、获得方法及其用途。本发明涉及通过重组菌株发酵获得的卵裂霉素衍生物。本发明还涉及用于获得重组菌株和生产卵霉素衍生物的方法。本发明还涉及可用于生产卵裂霉素衍生物的细菌菌株。最后，上述卵裂霉素衍生物适用于人类健康领域，特别是用于生产治疗肿瘤疾病的药物。
• Synthesis of novel asymmetric bow-tie PAMAM dendrimer-based conjugates for tumor-targeting drug delivery
  申请人：THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

  公开号：US10029014B2

  公开（公告）日：2018-07-24

  The present disclosure relates to a dendrimer-based conjugate of the formula Vm-D-C-D′-(T-F)n, which is useful for tumor targeting drug delivery. The use of asymmetric dendrimers allow for specific targeting as well as synthetic reproducibility.

  本公开涉及一种基于树枝状聚合物的Vm-D-C-D′-(T-F)n式共轭物，可用于肿瘤靶向给药。使用不对称树枝状聚合物可实现特异性靶向以及合成的可重复性。
• Gastrointestinal tract detection methods, devices and systems
  申请人：Progenity Inc.

  公开号：US10610104B2

  公开（公告）日：2020-04-07

  The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

  本公开涉及胃肠道（GI）检测方法、装置和系统。
• Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
  申请人：Progenity, Inc.

  公开号：US10980739B2

  公开（公告）日：2021-04-20

  This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor.

  本公开的内容包括使用趋化因子/趋化因子受体抑制剂治疗胃肠道疾病的方法和组合物。