Jaboticabin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: Jaboticabin
• 英文别名: [3,5-dihydroxy-2-(2-methoxy-2-oxoethyl)phenyl] 3,4-dihydroxybenzoate
• 化学式: C₁₆H₁₄O₈
• 分子量: 334.28
• InChiKey: LFLJQGHNYLKTBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Bioactive Depside and Anthocyanin Compounds, Compositions, and Methods of Use
  申请人：D'Armiento Jeanine

  公开号：US20110110885A1

  公开（公告）日：2011-05-12

  Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH 3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a condition, such as for example, chronic obstructive pulmonary disease (COPD) by administering an effective amount of a composition containing such compounds are also provided. Further provided is an extract obtained from the fruit of Myrciaria cauliflora containing at least one compound of the present invention in substantially pure form.

  本文提供了通过向细胞注射有效量的脲苷或花青素来调节化学趋化因子水平的方法。更具体地，本文提供了一种通过向细胞注射具有公式（IV）结构的脲苷的有效量来调节化学趋化因子水平的方法：公式（IV）其中R选自H或CH3，或选择青藤花苷、海棠花苷3-葡萄糖苷或其组合的花青素，或其对映体、光学异构体、对映异构体、N-氧化物、结晶形式、水合物或药学上可接受的盐。还提供了根据公式I-IV的化合物、制药组合物、单位剂量形式以及含有这些化合物的食品或饲料补充剂。本文还提供了通过注射含有这些化合物的组合物的有效量来治疗哺乳动物的疾病和治疗或缓解疾病的方法，例如慢性阻塞性肺疾病（COPD）。此外，本文还提供了从Myrciaria cauliflora果实中提取得到的至少一种本发明化合物的纯度高的提取物。
• BIOACTIVE DEPSIDE AND ANTHOCYANIN COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
  申请人：D'Armiento Jeanine

  公开号：US20150011629A1

  公开（公告）日：2015-01-08

  Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH 3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a condition, such as for example, chronic obstructive pulmonary disease (COPD) by administering an effective amount of a composition containing such compounds are also provided. Further provided is an extract obtained from the fruit of Myrciaria cauliflora containing at least one compound of the present invention in substantially pure form.

  本发明提供了通过向细胞中添加有效量的脲苷或花青素来调节化学趋化因子水平的方法。更具体地，本发明提供了一种通过向细胞中添加具有公式（IV）结构的有效量的脲苷来调节化学趋化因子水平的方法：公式（IV）其中R选自H或CH3，或选自花青苷3-葡萄糖苷、洋紫菜苷3-葡萄糖苷或两者的组合物、对映体、光学异构体、对映异构体、N-氧化物、结晶形式、水合物或其药学上可接受的盐。本发明还提供了根据公式I-IV的化合物、制药组合物、单位剂量形式以及含有这些化合物的食品或饲料补充剂。本发明还提供了通过向哺乳动物中给予含有这些化合物的组合物的有效量来治疗疾病的方法，以及治疗或改善疾病（例如慢性阻塞性肺病（COPD））的方法。本发明还提供了从Myrciaria cauliflora的果实中提取的至少含有本发明中一种化合物的纯形式的提取物。
• [EN] PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF<br/>[FR] DÉRIVÉ DE PHOSPHAMIDE, SON PROCÉDÉ DE FABRICATION ET SES UTILISATIONS<br/>[ZH] 一种磷酰胺衍生物及制备方法和用途
  申请人：SICHUAN HAISCO PHARMACEUTICAL CO LTD

  公开号：WO2017133517A1

  公开（公告）日：2017-08-10

  公开了一种磷酰胺衍生物及制备方法和用途。特别公开了一种通式(I)所示化合物及其药学上可接受的盐或立体异构体 (I)，其中，G、L、Q、s如说明书中所定义。
• US8846757B2
  申请人：——

  公开号：US8846757B2

  公开（公告）日：2014-09-30
• [EN] BIOACTIVE DEPSIDE AND ANTHOCYANIN COMPOUNDS, COMPOSITIONS, AND METHODS OF USE<br/>[FR] COMPOSÉS BIOACTIFS À BASE DE DEPSIDE ET D'ANTHOCYANINES, PRODUITS LES CONTENANT ET PROCÉDÉS D'UTILISATION
  申请人：UNIV COLUMBIA

  公开号：WO2008016593A2

  公开（公告）日：2008-02-07

  [EN] Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH₃ or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a condition, such as for example, chronic obstructive pulmonary disease (COPD) by administering an effective amount of a composition containing such compounds are also provided. Further provided is an extract obtained from the fruit ofMyrciaria ca?liflora containing at least one compound of the present invention in substantially pure form.
  [FR] La présente invention se rapporte à des procédés de modulation du niveau d'une chimiokine présente dans une cellule par administration à la cellule d'une quantité efficace d'un depside ou d'une anthocyanine. La présente invention se rapporte, plus particulièrement, à un procédé de modulation du niveau d'une chimiokine présente dans une cellule par administration à la cellule d'une quantité efficace d'un depside présentant la structure de la formule (IV), dans laquelle R est choisi parmi H ou CH₃, ou encore d'une anthocyanine choisie parmi la cyanidine 3-glucoside, la delphinidine 3-glucoside ou des combinaisons de celles-ci, ou encore d'un énantiomère, d'un isomère optique, d'un diastéréoisomère, d'un N-oxyde, d'une forme cristalline, d'un hydrate ou d'un sel acceptable sur le plan pharmaceutique de ceux-ci. La présente invention se rapporte également à des composés selon les formules I à IV, à des produits pharmaceutiques, à des formes pharmaceutiques en dose unitaire et à des aliments ou des compléments alimentaires contenant lesdits composés. Sont également proposés des procédés de traitement d'une affection chez un mammifère, ainsi que des procédés de traitement ou d'amélioration d'une affection, telle que, par exemple, la broncho-pneumopathie chronique obstructive, en administrant une quantité efficace d'un produit contenant lesdits composés. Est encore proposé un extrait obtenu à partir du fruit de Myrciaria cauliflora contenant au moins un composé de la présente invention sous une forme essentiellement pure.