[2,3-Bis(phosphanyl)cyclohexyl]phosphane

• 分子结构分类: 有机化合物 - 有机磷化合物
• 英文名称: [2,3-Bis(phosphanyl)cyclohexyl]phosphane
• 英文别名: [2,3-bis(phosphanyl)cyclohexyl]phosphane
• 化学式: C₆H₁₅P₃
• 分子量: 180.1
• InChiKey: JJHFVFMFRPHISU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• Esterases and related nucleic acids and methods
  申请人：Verenium Corporation

  公开号：EP2216403A2

  公开（公告）日：2010-08-11

  The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g. phosphplipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.

  本发明提供水解酶、编码水解酶的多核苷酸以及制造和使用这些多核苷酸和多肽的方法。在一个方面，本发明涉及具有水解酶活性的多肽，如酶，如酯酶、酰化酶、脂肪酶、磷脂酶、酯酶、酰化酶、脂肪酶、磷脂酶（如磷脂酶 A、B、C 和 D 活性、酪蛋白活性、脂质酰基水解酶（LAH）活性）或蛋白酶活性，包括恒温和耐热水解酶活性，以及编码这些酶的多核苷酸，以及制造和使用这些多核苷酸和多肽。本发明多肽的水解酶活性包括酯酶活性、脂肪酶活性（水解脂质）、酸解反应（用游离脂肪酸取代酯化脂肪酸）、酯交换反应（甘油三酯之间脂肪酸的交换）、酯合成、酯交换反应、磷脂酶活性和蛋白酶活性（水解肽键）。本发明的多肽可用于各种医药、农业和工业领域，包括化妆品和营养保健品的生产。另一方面，本发明的多肽可用于合成对映体纯手性产品。