Ecgonin | 876657-17-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: Ecgonin
• 英文别名: 3-hydroxy-8-methyl-8-azoniabicyclo[3.2.1]octane-2-carboxylate
• CAS: 876657-17-9
• 化学式: C₉H₁₅NO₃
• 分子量: 185.223
• InChiKey: PHMBVCPLDPDESM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method for preparing organoboron derivative containing oxygen and aromatic ring as labeled precursor of dopamine positron emission tomography imaging agent
  申请人：INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.

  公开号：US10934314B1

  公开（公告）日：2021-03-02

  A method for preparing organoboron derivatives containing oxygen atoms and an aromatic ring as labeled precursors of dopamine positron emission tomography imaging agents is revealed. Hydrochloride salt of cocaine is used as an initiator. Organoboron derivatives containing oxygen atoms are directly produced on an aromatic ring as drug substances and the aromatic ring is directly labeled with radioisotope fluorine-18 (F-18). The method takes only five steps including four steps for preparing organoboron derivatives containing oxygen atoms and an aromatic ring as drug substances and a step of labeling the aromatic ring of the organoboron derivatives with F-18 directly. Not only the process time is significantly reduced, the total yield rate is also improved effectively.

  揭示了一种制备含氧原子和芳香环的有机硼衍生物作为多巴胺正电子发射断层扫描成像剂的标记前体的方法。可卡因的盐酸盐被用作引发剂。含氧原子的有机硼衍生物直接在芳香环上生成作为药物物质，并且芳香环直接标记了放射性同位素氟-18（F-18）。该方法仅需五个步骤，包括四个步骤用于制备含氧原子和芳香环的有机硼衍生物作为药物物质，以及一步用于直接将有机硼衍生物的芳香环标记为F-18。不仅显著缩短了过程时间，还有效提高了总产率。
• INHIBITION OF BETA-AMYLOID PEPTIDE AGGREGATION
  申请人：Hess George P.

  公开号：US20100069468A1

  公开（公告）日：2010-03-18

  The present invention relates to methods of using cocaine-binding-site ligands and cocaine-binding-site RNA aptamers to treat or prevent Alzheimer's Disease and to reduce or prevent aggregation of beta-amyloid peptides in a subject.
• THERAPEUTIC TREATMENT FOR DRUG POISONING AND ADDICTION
  申请人：ADISPELL, INC.

  公开号：US20160193202A1

  公开（公告）日：2016-07-07

  The present invention relates to methods of treating or preventing drug poisoning and drug addiction in a subject. These methods involve administering to a subject in need of said treatment or prevention a ligand which binds to a regulatory site on the nicotinic acetylcholine receptor.
• HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR ANALYZING IMAGING AGENT, PRECURSOR OF IMAGING AGENT, OR INTERMEDIATE OF IMAGING AGENT
  申请人：INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.

  公开号：US20170115259A1

  公开（公告）日：2017-04-27

  A high performance liquid chromatography method of an imaging agent, a precursor of the imaging agent, or an intermediate of the imaging agent is revealed. Instead of using the same eluent, a first eluent with a lower proportion of methanol is used to elute target compounds. Then a second eluent having a higher ratio of methanol ranging from 95-99% is used to elute for at least 15 minutes. Next use the first eluent again to elute for at least 60 minutes. Thus the target compounds are retained stably in the column and retention time of respective reproductive characteristic peak is obtained.
• PREPARATION OF (-)-COCAINE HYDROCHLORIDE
  申请人：Cody Laboratories, Inc.

  公开号：US20190224184A1

  公开（公告）日：2019-07-25

  Efficient methods are provided for large scale production of ethyl cocaine-free cocaine hydrochloride. Compositions and methods comprising administration of cocaine hydrochloride are provided.