trigallic acid | 2131-66-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: trigallic acid
• 英文别名: m-Trigallussaeure；Trigallic Acid；3-[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy-4,5-dihydroxybenzoic acid
• CAS: 2131-66-0
• 化学式: C₂₁H₁₄O₁₃
• 分子量: 474.334
• InChiKey: QUXNYZHQBWMPNX-UHFFFAOYSA-N

物化性质

• 熔点：
  216 °C
• 沸点：
  910.1±65.0 °C(Predicted)
• 密度：
  1.839±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  232
• 氢给体数：
  8
• 氢受体数：
  13

文献信息

• Inhibitors of D-amino acid oxidase (DAAO) and uses thereof
  申请人：SyneuRx International (Taiwan) Corp.

  公开号：US10927138B2

  公开（公告）日：2021-02-23

  Provided herein are compounds of Formula (I) and uses thereof for inhibiting the activity of D-amino acid oxidase (DAAO) or treating diseases or disorders associated with DAAO, such as a central nervous system (CNS) disorder, obesity, diabetes, or hyperlipidemia. Also provided in the present disclosure are methods of synthesizing the Formula (I) compounds described herein.

  本文提供了式(I)化合物及其用途，用于抑制D-氨基酸氧化酶（DAAO）的活性或治疗与DAAO相关的疾病或紊乱，如中枢神经系统（CNS）紊乱、肥胖、糖尿病或高脂血症。本公开还提供了合成所述式（I）化合物的方法。
• Compounds and pharmaceutical uses thereof
  申请人：SyneuRx International (Taiwan) Corp.

  公开号：US11382924B2

  公开（公告）日：2022-07-12

  A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

  一种治疗冠状病毒感染的方法，包括向有需要的受试者施用有效量的组合物，其中组合物包含一种或多种式（I）化合物： 或其药学上可接受的盐。
• INHIBITORS OF D-AMINO ACID OXIDASE AND USES THEREOF
  申请人：SyneuRx International (Taiwan) Corp.

  公开号：US20210214385A1

  公开（公告）日：2021-07-15

  Provided herein are potent compounds of Formula (I) and uses thereof for inhibiting the activity of D-amino acid oxidase (DAAO) or treating diseases or disorders associated with DAAO, such as a central nervous system (CNS) disorder, pain, obesity, diabetes, or hyperlipidemia. Also provided in the present disclosure are methods of synthesizing the Formula (I) compounds described herein. (I)
• COMPOUNDS AND PHARMACEUTICAL USES THEREOF
  申请人：SyneuRx International (Taiwan) Corp.

  公开号：US20220054516A1

  公开（公告）日：2022-02-24

  A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
• [EN] POTENT INHIBITORS OF D-AMINO ACID OXIDASE (DAAO) AND USES THEREOF<br/>[FR] INHIBITEURS PUISSANTS DE LA D-AMINOACIDE OXYDASE (DAAO) ET LEURS UTILISATIONS
  申请人：SYNEURX INT TAIWAN CORP

  公开号：WO2019228408A1

  公开（公告）日：2019-12-05

  Provided herein are potent compounds of Formula (I) and uses thereof for inhibiting the activity of D-amino acid oxidase (DAAO) or treating diseases or disorders associated with DAAO, such as a central nervous system (CNS) disorder, pain, obesity, diabetes, or hyperlipidemia. Also provided in the present disclosure are methods of synthesizing the Formula (I) compounds described herein. (I)