4-nonyllphenyl benzoate | 6316-62-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 4-nonyllphenyl benzoate
• 英文别名: benzoic acid-(4-nonyl-phenyl ester)；Benzoesaeure-(4-nonyl-phenylester)；4-Nonylphenyl benzoate；(4-nonylphenyl) benzoate
• CAS: 6316-62-7
• 化学式: C₂₂H₂₈O₂
• 分子量: 324.463
• InChiKey: UHNDOFZFNNZFIW-UHFFFAOYSA-N

物化性质

• 沸点：
  439.2±24.0 °C(Predicted)
• 密度：
  1.010±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-nonyllphenyl benzoate 、 三氯化铝 以39%的产率得到
  参考文献：
  名称：

  RAZUS, A. C.;ARVAY, Z.;BARTHA, E.;CONDEIU, C.;GLATZ, A. M., REV. CHIM., RSR, 1985, 36, N 4, 299-302

  摘要：

  DOI：
• 作为产物：
  描述：

  对壬基酚 生成 4-nonyllphenyl benzoate
  参考文献：
  名称：

  Pigment epithelial detachment in the elderly

  摘要：

  Background: A prospective analysis was performed to characterize the angiographic appearance, natural course and prognosis of serous pigment epithelial detachments (PEDs) in elderly patients. The aim was to differentiate PEDs according to their angiographic characteristics and to analyze the specific clinical, visual and morphologic course of the different PEDs. Methods: Fluorescein and indocyanine green angiography were performed in 10 1 consecutive patients (53-87 years; 63 female, 38 male) with clinical signs of serous PED and drusen. Results: Different types of serous PED were identified: polypoidal choroidal vasculopathy (PCV)-associated PED in 14 patients (13.9%), vascular PED in 72 (71.2%), and avascular PED in 15 (14.9%). All PEDs resulted initially in similar visual loss. Avascular PEDs were smaller than vascular PEDs, and the latter were smaller than PCV-PEDs. During follow-up these differences were always present, but all PEDs enlarged initially followed by regression. This course was associated in all PEDs with progressive visual loss, accompanied by the development of RPE atrophy in avascular PEDs or disciform scars or RPE tears in the two other types. Conclusion: Despite different associations, all PEDs have a similar clinical course with respect to visual loss and enlargement or regression. This is compatible with the proposed common pathogenetic background with a hydrophobic barrier in Bruch's membrane causing fluid resulting from RPE pumping activity to accumulate between the pigment epithelium and Bruch's membrane.

  DOI：

  10.1007/s00417-002-0505-8

文献信息

• Metal-free synthesis of aryl esters by coupling aryl carboxylic acids and aryl boronic acids
  作者：Jayaraman Sembian Ruso、Nagappan Rajendiran、Rajendran Senthil Kumaran

  DOI：10.1016/j.tetlet.2014.02.079

  日期：2014.4

  A facile synthesis of aryl esters is developed by coupling aryl carboxylic acids and aryl boronic acids in the presence of PhI(OAc)2 and carbonyl diimidazole. A wide range of functional groups were tolerant to the metal-free reaction condition that led to the desired products in good yields.

  通过在PhI（OAc）2和羰基二咪唑存在下偶联芳基羧酸和芳基硼酸，可以轻松合成芳基酯。宽泛的官能团可耐受无金属的反应条件，从而可以高收率得到所需的产物。
• Sarang C., Rao Y. R., Ind. and Eng. Chem. Res, 33 (1994) N 7, S 1665-1668
  作者：Sarang C., Rao Y. R.

  DOI：——

  日期：——
• SZYMANOWSKI, J.;BLASZCZAK, J., CHEM. STOSOW., 1982, 26, N 1, 99-109
  作者：SZYMANOWSKI, J.、BLASZCZAK, J.

  DOI：——

  日期：——
• OLSZANOWSKI A.; WISNIEWSKI M.; SZYMANOWSKI J., CHEM. STOSOW., 30,(1986) N 3, 439-446
  作者：OLSZANOWSKI A.、 WISNIEWSKI M.、 SZYMANOWSKI J.

  DOI：——

  日期：——
• Pigment epithelial detachment in the elderly
  作者：D. Pauleikhoff、D. Löffert、G. Spital、M. Radermacher、J. Dohrmann、A. Lommatzsch、A. Bird

  DOI：10.1007/s00417-002-0505-8

  日期：2002.7

  Background: A prospective analysis was performed to characterize the angiographic appearance, natural course and prognosis of serous pigment epithelial detachments (PEDs) in elderly patients. The aim was to differentiate PEDs according to their angiographic characteristics and to analyze the specific clinical, visual and morphologic course of the different PEDs. Methods: Fluorescein and indocyanine green angiography were performed in 10 1 consecutive patients (53-87 years; 63 female, 38 male) with clinical signs of serous PED and drusen. Results: Different types of serous PED were identified: polypoidal choroidal vasculopathy (PCV)-associated PED in 14 patients (13.9%), vascular PED in 72 (71.2%), and avascular PED in 15 (14.9%). All PEDs resulted initially in similar visual loss. Avascular PEDs were smaller than vascular PEDs, and the latter were smaller than PCV-PEDs. During follow-up these differences were always present, but all PEDs enlarged initially followed by regression. This course was associated in all PEDs with progressive visual loss, accompanied by the development of RPE atrophy in avascular PEDs or disciform scars or RPE tears in the two other types. Conclusion: Despite different associations, all PEDs have a similar clinical course with respect to visual loss and enlargement or regression. This is compatible with the proposed common pathogenetic background with a hydrophobic barrier in Bruch's membrane causing fluid resulting from RPE pumping activity to accumulate between the pigment epithelium and Bruch's membrane.