4-((4-(dimethylamino)phenyl)diazenyl)-3-nitrobenzaldehyde | 93734-58-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 偶氮苯
• 英文名称: 4-((4-(dimethylamino)phenyl)diazenyl)-3-nitrobenzaldehyde
• 英文别名: 4-(4-dimethylamino-phenylazo)-3-nitro-benzaldehyde
• CAS: 93734-58-8
• 化学式: C₁₅H₁₄N₄O₃
• 分子量: 298.301
• InChiKey: RLVCVEYRFMKHLF-WUKNDPDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.89
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  88.17
• 氢给体数：
  0.0
• 氢受体数：
  6.0

文献信息

• OLIGONUCLEOTIDE PROBE AND USE THEREOF
  申请人：ASANUMA Hiroyuki

  公开号：US20110229980A1

  公开（公告）日：2011-09-22

  The present teaching provides a fluorescent oligonucleotide probe having a high degree of design flexibility and wide applicability, as well as the use thereof. This is an oligonucleotide probe capable of forming a stem and loop, comprising at least one fluorophore located between adjacent nucleotides in the stem and is linked to a unit represented by Formula (1) and at least one quencher located at a site capable of pairing up with the at least one fluorophore located between the adjacent nucleotides in the stem and is linked to a unit represented by Formula (2). (In the formulae, X represents the fluorophore, Y represents the quencher, R1 represents an optionally substituted C 2 or C 3 alkylene chain, R2 represents an optionally substituted C 0-2 alkylene chain, and Z represents a direct bond or linker.)

  本教学提供了一种具有高度设计灵活性和广泛适用性的荧光寡核苷酸探针及其使用。这是一种能够形成茎环的寡核苷酸探针，包括至少一个荧光物质位于茎中相邻核苷酸之间，并与由式（1）表示的单元连接，以及至少一个淬灭剂位于能够与茎中相邻核苷酸之间的至少一个荧光物质配对的位置，并与由式（2）表示的单元连接。（在公式中，X代表荧光物质，Y代表淬灭剂，R1代表可选择地取代的C2或C3烷基链，R2代表可选择地取代的C0-2烷基链，Z代表直接键或连接物。）