(+/-) trans-octahydro-1-propyl-6(2H)-quinolinone | 92343-60-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉类
• 英文名称: (+/-) trans-octahydro-1-propyl-6(2H)-quinolinone
• 英文别名: trans-(+/-)-1-n-propyl-6-oxo-decahydroquinoline；trans-(+/-)-1-n-propyl-6-oxodecahydroquinoline；4aS,8aS-1-n-propyl-6-oxodecahydroquinoline；trans-1-n-propyl-6-oxodecahydroquinoline；(4AS,8aS)-1-propyloctahydroquinolin-6(2H)-one；(4aS,8aS)-1-propyl-2,3,4,4a,5,7,8,8a-octahydroquinolin-6-one
• CAS: 92343-60-7
• 化学式: C₁₂H₂₁NO
• 分子量: 195.305
• InChiKey: FWHLCAXBTREMQT-JQWIXIFHSA-N

物化性质

• 沸点：
  288.3±33.0 °C(Predicted)
• 密度：
  0.976±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-) trans-octahydro-1-propyl-6(2H)-quinolinone 在 氢溴酸 、 溴 作用下， 以 溶剂黄146 为溶剂， 生成 4aS,8aS-1-n-propyl-6-oxo-7-bromodecahydroquinoline dihydrobromide
  参考文献：
  名称：

  Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion

  摘要：

  转-（.+-。）2和/或5-可替代的八氢噻唑并并[4,5-g]喹啉及其酸加成物或季铵盐，以及其各自的对映体，可用作多巴胺激动剂。

  公开号：

  US04537893A1
• 作为产物：
  描述：

  (4aS,8aS)-6-methoxy-1-propyl-3,4,4a,5,8,8a-hexahydro-2H-quinoline 生成 (+/-) trans-octahydro-1-propyl-6(2H)-quinolinone
  参考文献：
  名称：

  SCHAUS, J. M.

  摘要：

  DOI：

文献信息

• Trans-(
  申请人：Eli Lilly and Company

  公开号：US04501890A1

  公开（公告）日：1985-02-26

  Trans-(.+-.)-2-Amino or substituted amino-4-permissibly-substituted 6-lower alkyl or allyl-5,5a,-6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinolines, the corresponding trans-(-)-stereoisomers and salts thereof, useful in treating anxiety, Parkinson's Syndrome, sexual dysfunction, depression, hypertension and elevated prolactin levels, and intermediates useful for the synthesis thereof.

  2-氨基或取代氨基的4-允许取代的6-较低的烷基或烯丙基-5,5a,-6,7,8,9,9a,10-八氢吡咯[4,5-g]喹啉的trans-(-)-立体异构体及其盐，用于治疗焦虑、帕金森综合征、性功能障碍、抑郁症、高血压和升高的催乳素水平，以及用于合成的中间体。
• 2-Mercaptopyrimidohexahydroquinolines and related compounds
  申请人：Eli Lilly and Company

  公开号：US04507478A1

  公开（公告）日：1985-03-26

  Trans-(.+-.) or trans-(-)-2,4-permissibly-substituted-6-alkyl or allyl octahydropyrimido[4,5-g]quinolines and related compounds, ultraviolet light absorbers.

  翻译结果：转-(.+-.)或转-(-)-2,4-可允许取代的6-烷基或烯丙基辛烷基吡啶并[4,5-g]喹啉和相关化合物，紫外线吸收剂。
• Process for the preparation of octahydro-oxazolo [4,5-G]quinolines
  申请人：Eli Lilly and Company

  公开号：US04659832A1

  公开（公告）日：1987-04-21

  Trans-(.+-.)-2- and/or -5-permissibly substituted octahydro-oxazolo[4,5-g]quinolines, acid addition salts thereof and individual enantiomers thereof, useful as dopamine agonists or intermediates of the preparation of dopamine agonists.

  可允许取代的Trans-(.+-.)-2-和/或-5-辛烷氧杂-4,5-g-喹啉，以及它们的酸加成盐和单体对映体，可用作多巴胺激动剂或多巴胺激动剂的制备中间体。
• Pyrimido(4,5-g)quinolines, process for their preparation, and pharmaceutical compositions containing them
  申请人：ELI LILLY AND COMPANY

  公开号：EP0139393A2

  公开（公告）日：1985-05-02

  Trans-(±)-2-Amino (or substituted amino)-4-(permissibly-substituted)-6-C1-C3 alkyl (or allyl)-5,5a,-6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinolines, the corresponding trans-(-) and trans-(+)-stereoisomers and salts thereof, useful in treating Parkinson's Syndrome, sexual dysfunction, depression, hypertension, and prolactin related diseases, and intermediates useful for the synthesis thereof, are disclosed. The products are prepared by condensing an appropriate ketone with the appropriately substituted guanidine.

  本发明涉及转型-(±)-2-氨基(或取代氨基)-4-(可取代基)-6-C1-C3烷基(或烯丙基)-5,5a,-6,7,8,9,9a,10-八氢嘧啶[4,5-g]喹啉，相应的转型-(-)和转型-(+)-立体异构体及其盐，用于治疗帕金森综合症、性功能障碍、抑郁症、高血压和催乳素相关疾病，以及用于其合成的中间体。所述产品通过将适当的酮与适当取代的胍缩合制备而成。
• Octahydro-2H-pyrrolo(3,4-g)quinolines, process for their preparation and pharmaceutical compositions containing them
  申请人：ELI LILLY AND COMPANY

  公开号：EP0013788A1

  公开（公告）日：1980-08-06

  Octahydro-2H-pyrrolo[3,4-g]quinolines, useful as dopamine agonists, particularly as inhibitors of prolactin secretion and in treatment of Parkinsonism, are described herein. These novel compounds are prepared by reacting a 2-alkylcarbonyloctahydro-2H-pyrrolo[3,4-g]quinoline with base.

  本文描述了八氢-2H-吡咯并[3,4-g]喹啉，可用作多巴胺激动剂，特别是催乳素分泌抑制剂和帕金森病治疗剂。这些新型化合物是通过 2-烷基羰基八氢-2H-吡咯并[3,4-g]喹啉与碱反应制备的。