2-oxo-3-phenyl-N-[4-(2-pyridinyl)-1,3-thiazol-2-yl]-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxamide hydrochloride | 1044574-02-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 2-oxo-3-phenyl-N-[4-(2-pyridinyl)-1,3-thiazol-2-yl]-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxamide hydrochloride
• 英文别名: 2-Oxo-3-phenyl-N-[4-(2-pyridinyl)-1,3-thiazol-2-yl]-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxamide hydrochloride；2-oxo-3-phenyl-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxamide;hydrochloride
• CAS: 1044574-02-8
• 化学式: C₂₂H₂₁N₅O₃S*ClH
• 分子量: 471.967
• InChiKey: BMQMJEQKLYOSGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.65
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-oxo-3-phenyl-N-[4-(2-pyridinyl)-1,3-thiazol-2-yl]-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxamide 在 盐酸 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 0.5h， 以95%的产率得到2-oxo-3-phenyl-N-[4-(2-pyridinyl)-1,3-thiazol-2-yl]-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxamide hydrochloride
  参考文献：
  名称：

  WO2008/92887

  摘要：

  公开号：

文献信息

• I-OXA-3-Azaspiro (4.5) Decan-2-One And 1-OXA-3, 8-Diazaspiro (4.5) Decan-2-One Derivatives For The Treatment of Eating Disorders
  申请人：Bentley Jonathan

  公开号：US20100197699A1

  公开（公告）日：2010-08-05

  The present invention relates to novel compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R is an aryl or heteroaryl; which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; W is —CZ 1 or nitrogen; Z 1 is hydrogen, C1-C4 alkyl; A is a 5 membered heteroaryl, pyrazine, pyrimidine, or quinoline or quinazoline which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; B is hydrogen or a 5-10 membered aryl or heteroaryl which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; being A and B linked via any atom; provided that when W is —CZ 1 , compounds of formula (I) have a trans stereochemistry; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY Y5 receptor antagonists and as agents for the treatment and/or prophylaxis of eating disorders such as a binge eating disorder.

  本发明涉及式（I）的新化合物，或其药学上可接受的盐或溶剂，其中R是芳基或杂环芳基；可以被一个或多个卤素，C1-C4烷基，C1-C4烷氧基，C1-C4卤代烷基，C1-C4卤代烷氧基，氰基取代；W是—CZ1或氮；Z1是氢，C1-C4烷基；A是5元杂环芳基，吡嗪，嘧啶或喹啉或喹嗪，可以被一个或多个卤素，C1-C4烷基，C1-C4烷氧基，C1-C4卤代烷基，C1-C4卤代烷氧基，氰基取代；B是氢或一个5-10元芳基或杂环芳基，可以被一个或多个卤素，C1-C4烷基，C1-C4烷氧基，C1-C4卤代烷基，C1-C4卤代烷氧基，氰基取代；A和B通过任何原子连接；但当W是—CZ1时，式（I）的化合物具有反式立体化学；其制备方法，用于这些方法的中间体，包含它们的药物组合物以及它们作为NPY Y5受体拮抗剂和治疗和/或预防暴食障碍的药物代理的用途。