申请人:Ningxia Medical University
公开号:US20200147242A1
公开(公告)日:2020-05-14
A magnetic, thermosensitive, fluorescent micelle includes a core, a carrier wrapping the core, and a plurality of water-soluble near-infrared CdHgTe quantum dots (QD) disposed on the carrier. The core includes dextran-magnetic layered double hydroxide-fluorouracil (DMF). The carrier includes a tripolymer of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-polylactic acid (PLA). N-isopropylacrylamide-co-N,N-dimethylacrylamide of the tripolymer includes a hydrophilic group and a hydrophobic carbon frame. The hydrophilic group is oriented outwards with respect to the and forms a shell. The hydrophobic carbon frame and polylactic acid are restrained to wrap the dextran-magnetic layered double hydroxide-fluorouracil to form the core.
一种磁性、热敏感、荧光微胶束包括一个核心,包裹核心的载体,以及多个水溶性近红外CdHgTe量子点(QD)分布在载体上。核心包括右旋糖基-磁性层状双氢氧化物-氟尿嘧啶(DMF)。载体包括聚(N-异丙基丙烯酰胺-co-N,N-二甲基丙烯酰胺)-b-聚乳酸(PLA)的三聚物。三聚物的N-异丙基丙烯酰胺-co-N,N-二甲基丙烯酰胺包括一个亲水基团和一个疏水碳骨架。亲水基团朝外并形成一个壳。疏水碳骨架和聚乳酸被限制包裹右旋糖基-磁性层状双氢氧化物-氟尿嘧啶以形成核心。