thymidine 3'-(1,2-dipalmitoyl-sn-glycero-3-phosphate) | 1160002-70-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核糖核苷3'-磷酸盐
• 英文名称: thymidine 3'-(1,2-dipalmitoyl-sn-glycero-3-phosphate)
• 英文别名: [(2R)-2-hexadecanoyloxy-3-[hydroxy-[(2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphoryl]oxypropyl] hexadecanoate
• CAS: 1160002-70-9
• 化学式: C₄₅H₈₁N₂O₁₂P
• 分子量: 873.118
• InChiKey: ZEHTWVQCVABVPA-LLIMXKFASA-N

物化性质

• 密度：
  1.13±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  12.4
• 重原子数：
  60
• 可旋转键数：
  40
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  187
• 氢给体数：
  3
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  1,5-diazabicyclo[5.4.0]undec-7-ene (DBU) 、 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine,3'-[(2-cyano-ethyl)-N,N-diisopropyl)]phosphoramidite 、 碘 、 1,2-二棕榈酰-sn-丙三醇 生成 thymidine 3'-(1,2-dipalmitoyl-sn-glycero-3-phosphate)
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Method for Preparing Nanoparticles Based on Functional Amphiphilic Molecules or Macromolecules, and the Use Thereof
  申请人：Barthelemy Philippe

  公开号：US20110059180A1

  公开（公告）日：2011-03-10

  The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorisation of therapeutic agents, especially anti-tumoral agents.

  这项发明涉及一种基于功能性两性分子或大分子制备纳米颗粒的方法，可选地在至少一种胆固醇类物质的存在下，使治疗剂，特别是抗肿瘤剂的封装成为可能，并且用于运输和载体化治疗剂，特别是抗肿瘤剂。
• FUNCTIONAL AMPHIPILIC MOLECULE OR MACROMOLECULE FORMULATIONS WITH MULTIPLE COMPARTMENTS
  申请人：Barthelemy Philippe

  公开号：US20120070505A1

  公开（公告）日：2012-03-22

  The invention relates to novel functional amphiphilic molecule or macromolecule formulations with multiple compartments for transporting or targeting at least one therapeutic agent, in particular an antitumor agent, as well as to a method for preparing such formulations and to the use thereof.

  本发明涉及一种新型的具有多个隔室的功能性两性分子或大分子配方，用于运输或靶向至少一种治疗剂，特别是抗肿瘤剂，以及制备这种配方的方法和使用方法。
• METHOD FOR PREPARING NANOPARTICLES BASED ON FUNCTIONAL AMPHIPHILIC MOLECULES OR MACROMOLECULES, AND THE USE THEREOF
  申请人：UNIVERSITE VICTOR SEGALEN BORDEAUX 2

  公开号：US20140308343A1

  公开（公告）日：2014-10-16

  The invention relates to a method for preparing nanoparticles based on functional amphiphilic molecules or macromolecules, optionally in the presence of at least one colipide, enabling the encapsulation of therapeutic agents, especially anti-tumoral agents, and the use thereof for the transport and vectorization of therapeutic agents, especially anti-tumoral agents.

  本发明涉及一种基于功能性两亲分子或大分子的纳米粒子制备方法，可选地在至少一种胆固醇类物质的存在下，使治疗剂，特别是抗肿瘤剂封装，并用于治疗剂，特别是抗肿瘤剂的输送和载荷。
• LIPID BASED NANOCARRIER COMPOSITIONS LOADED WITH METAL NANOPARTICLES AND THERAPEUTIC AGENT
  申请人：UNIVERSITE DE BORDEAUX

  公开号：EP3085360A1

  公开（公告）日：2016-10-26

  The invention relates to non-polymeric lipid-based nanocarrier compositions loaded with metal nanoparticles and at least one therapeutic agent, useful .as agents for transportation, vectorization, cellular delivery cellular targeting or cellular localization of at least one therapeutic agent.

  本发明涉及装有金属纳米颗粒和至少一种治疗剂的非聚合物脂基纳米载体组合物，可用作至少一种治疗剂的运输、载体化、细胞输送、细胞靶向或细胞定位的制剂。
• METHOD FOR METAL ION DETECTION IN AQUEOUS SOLUTIONS USING NUCLEOLIPID COMPOUNDS
  申请人：UNIVERSITE DE BORDEAUX

  公开号：EP3502684A1

  公开（公告）日：2019-06-26

  The invention relates to a method for metal ion detection in aqueous solutions, in particular silver or mercury, using nucleolipid compounds, and to new nucleolipid compounds which can be used in said method.

  本发明涉及一种利用核脂化合物检测水溶液中金属离子（尤其是银或汞）的方法，以及可用于上述方法的新型核脂化合物。