2-(pyridin-2-yl)-1,3-phenylene dibenzoate | 1220099-82-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: 2-(pyridin-2-yl)-1,3-phenylene dibenzoate
• 英文别名: (3-Benzoyloxy-2-pyridin-2-ylphenyl) benzoate
• CAS: 1220099-82-0
• 化学式: C₂₅H₁₇NO₄
• 分子量: 395.414
• InChiKey: XZCIHNOUFNZPQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-苯基吡啶 、 苯甲酸酐 在 氧气 、 copper diacetate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以84%的产率得到2-(pyridin-2-yl)-1,3-phenylene dibenzoate
  参考文献：
  名称：

  Copper(II)-Catalyzed Ortho-Acyloxylation of the 2-Arylpyridines sp² C−H Bonds with Anhydrides, Using O₂ as Terminal Oxidant

  摘要：

  A chelation-assisted copper(II)-catalyzed ortho-acyloxylation of the 2-arylpyridine sp(2) C-H bond with anhydride is described. The procedure tolerates various functional groups, such as carbomethoxyl, methoxyl fluoro, bromo, chloro, and cyano groups, affording the mono- or diacyloxylated products in moderate to good yields. Importantly, this procedure uses O-2 as a clean terminal oxidant.

  DOI：

  10.1021/jo1000719

文献信息

• Palladium catalyzed ortho-C–H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates
  作者：Qian Zhang、Ying Wang、Tingting Yang、Li Li、Dong Li

  DOI：10.1016/j.tetlet.2015.09.097

  日期：2015.10

  A palladium-catalyzed ortho-C-H-benzoxylation of 2-arylpyridines using iodobenzene dibenzoates has been developed. The reaction employed the stable and easily accessible hypervalent iodine reagents as both benzoxylate source and oxidant which made the protocol simple and facile. It showed high regioselectivity and good functional group tolerance, and gave the mono-benzoxylation products in moderate to excellent yields. (C) 2015 Elsevier Ltd. All rights reserved.