N-(trifluoroboratomethyl)thiomorpholine internal salt | 1268340-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻嗪类
• 英文名称: N-(trifluoroboratomethyl)thiomorpholine internal salt
• 英文别名: trifluoro(thiomorpholin-4-ium-4-ylmethyl)borate；(thiomorpholinium-4-ylmethyl)trifluoroborate；hydron;trifluoro(thiomorpholin-4-ylmethyl)boranuide
• CAS: 1268340-95-9
• 化学式: C₅H₁₀BF₃NS*H
• 分子量: 185.021
• InChiKey: VUNVVPNMYVRSKZ-UHFFFAOYSA-O

物化性质

• 熔点：
  146-156°C

计算性质

• 辛醇/水分配系数(LogP)：
  0.0
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-氯吡啶 、 N-(trifluoroboratomethyl)thiomorpholine internal salt 在 palladium diacetate 、 caesium carbonate 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 45.0h， 以39%的产率得到4-(pyridin-3-ylmethyl)thiomorpholine
  参考文献：
  名称：

  Reinvestigation of Aminomethyltrifluoroborates and Their Application in Suzuki−Miyaura Cross-Coupling Reactions

  摘要：

  A reinvestigation into the chemical composition of potassium aminomethyltrifluoroborates is reported. These trifluoroborato salts have been reassigned as zwitterionic ammoniomethyltrifluoroborates. Minor adjustments to the previously disclosed reaction conditions are reported that permit a similar level of activity as nucleophiles in Suzuki-Miyaura cross-coupling reactions.

  DOI：

  10.1021/jo2001066
• 作为产物：
  描述：

  硫代吗啉 、 potassium (chloromethyl)trifluoroborate 以 丙酮 为溶剂， 反应 16.0h， 以75%的产率得到N-(trifluoroboratomethyl)thiomorpholine internal salt
  参考文献：
  名称：

  Reinvestigation of Aminomethyltrifluoroborates and Their Application in Suzuki−Miyaura Cross-Coupling Reactions

  摘要：

  A reinvestigation into the chemical composition of potassium aminomethyltrifluoroborates is reported. These trifluoroborato salts have been reassigned as zwitterionic ammoniomethyltrifluoroborates. Minor adjustments to the previously disclosed reaction conditions are reported that permit a similar level of activity as nucleophiles in Suzuki-Miyaura cross-coupling reactions.

  DOI：

  10.1021/jo2001066

文献信息

• INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS
  申请人：ECKHARDT Matthias

  公开号：US20140221349A1

  公开（公告）日：2014-08-07

  Compounds of general formula I wherein the group R 1 is defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  通式I的化合物，其中基团R1如权利要求1所定义，具有有价值的药理学特性，特别是结合GPR40受体并调节其活性。这些化合物适用于治疗和预防可以受到该受体影响的疾病，例如代谢性疾病，特别是2型糖尿病。
• Indanyloxydihydrobenzofuranylacetic acids
  申请人：Eckhardt Matthias

  公开号：US08927531B2

  公开（公告）日：2015-01-06

  Compounds of general formula I wherein the group R1 is defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  通式I的化合物，其中基团R1如权利要求1所定义，具有有价值的药理学特性，特别是与GPR40受体结合并调节其活性。这些化合物适用于治疗和预防可以受该受体影响的疾病，例如代谢性疾病，特别是2型糖尿病。
• Cross-Coupling of Mesylated Phenol Derivatives with Potassium Ammonio- and Amidomethyltrifluoroborates
  作者：Gary A. Molander、Floriane Beaumard

  DOI：10.1021/ol200128y

  日期：2011.3.4

  A large array of aryl and heteroaryl mesylates have been successfully employed as electrophiles in a Csp(2)-Csp(3) Suzuki-Miyaura cross-coupling with potassium ammonio- and amidomethyltrifluoroborates to afford the corresponding products in high yields.
• Reinvestigation of Aminomethyltrifluoroborates and Their Application in Suzuki−Miyaura Cross-Coupling Reactions
  作者：Jessica Raushel、Deidre L. Sandrock、Kanth V. Josyula、Deborah Pakyz、Gary A. Molander

  DOI：10.1021/jo2001066

  日期：2011.4.15

  A reinvestigation into the chemical composition of potassium aminomethyltrifluoroborates is reported. These trifluoroborato salts have been reassigned as zwitterionic ammoniomethyltrifluoroborates. Minor adjustments to the previously disclosed reaction conditions are reported that permit a similar level of activity as nucleophiles in Suzuki-Miyaura cross-coupling reactions.