3-azaspiro[5.5]undecane-3-carboxamide | 1162762-73-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 3-azaspiro[5.5]undecane-3-carboxamide
• 英文别名: 3-Aza-spiro[5.5]undecane-3-carboxylic acid amide
• CAS: 1162762-73-3
• 化学式: C₁₁H₂₀N₂O
• 分子量: 196.293
• InChiKey: MKAJMGKRZCZDKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  三甲基硅基异氰酸酯 、 3-氮螺环[5,5]十一烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以82%的产率得到3-azaspiro[5.5]undecane-3-carboxamide
  参考文献：
  名称：

  Wang, Jun; Cady, Sarah D.; Balannik, Victoria, Journal of the American Chemical Society, 2009, vol. 131, p. 8066 - 8076

  摘要：

  DOI：

文献信息

• INHIBITION OF INFLUENZA M2 PROTON CHANNEL
  申请人：DeGrado William F.

  公开号：US20110288111A1

  公开（公告）日：2011-11-24

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

  提供了一些化合物，这些化合物能够通过与M2跨膜蛋白相互作用来调节甲型流感病毒的活性。同时还提供了一种治疗甲型流感受影响的疾病状态或感染的方法，包括给予含有已被鉴定为能够与M2蛋白相互作用的一个或多个化合物的组合物。
• USE OF JAK INHIBITORS IN PREPARATION OF DRUGS FOR TREATING JAK KINASE-RELATED DISEASES
  申请人：Zhuhai United Laboratories Co., Ltd

  公开号：EP4105214A1

  公开（公告）日：2022-12-21

  The invention discloses an application of JAK inhibitors [1,2,4]triazolo[1,5-a]pyridine compounds in the preparation and treatment of autoimmune, inflammatory or allergic diseases, transplantation rejection and other diseases. The JAK inhibitors [1,2,4]triazolo[1,5-a]pyridine compounds include the compounds shown in formula (I), their isomers or their pharmaceutically acceptable salts: the JAK inhibitors of the present invention have good efficacy in animal model tests of autoimmune, inflammatory or allergic diseases, especially in animal in vivo efficacy evaluation tests of inflammatory bowel disease and allergic dermatitis.

  本发明揭示了JAK抑制剂[1,2,4]三唑并[1,5-a]吡啶化合物在自身免疫性、炎症性或过敏性疾病、移植排斥等疾病的制备和治疗中的应用。JAK抑制剂[1,2,4]三唑并[1,5-a]吡啶化合物包括式(I)中所示的化合物、其异构体或其药学上可接受的盐：本发明的JAK抑制剂在自身免疫性、炎症性或过敏性疾病的动物模型测试中具有良好的疗效，尤其在炎症性肠病和过敏性皮炎的动物体内疗效评估测试中表现出色。
• US9453005B2
  申请人：——

  公开号：US9453005B2

  公开（公告）日：2016-09-27
• [EN] INHIBITION OF INFLUENZA M2 PROTON CHANNEL<br/>[FR] INHIBITION DU CANAL DU PROTON M2 DE LA GRIPPE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2010033339A1

  公开（公告）日：2010-03-25

  Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
• Wang, Jun; Cady, Sarah D.; Balannik, Victoria, Journal of the American Chemical Society, 2009, vol. 131, p. 8066 - 8076
  作者：Wang, Jun、Cady, Sarah D.、Balannik, Victoria、Pinto, Lawrence H.、DeGrado, William F.、Hong, Mei

  DOI：——

  日期：——