o-cresyl dihydrogen phosphate | 18351-85-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磷酸及其衍生物
• 英文名称: o-cresyl dihydrogen phosphate
• 英文别名: o-methylphenyl phosphate；Phosphorsaeure-(2-methyl-phenylester)；phosphoric acid mono-o-tolyl ester；Phosphorsaeure-mono-o-tolylester；o-Tolyl-dihydrogenphosphat；(2-Methylphenyl) Dihydrogen Phosphate
• CAS: 18351-85-4
• 化学式: C₇H₉O₄P
• 分子量: 188.12
• InChiKey: HUJOGFUFUMBXPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻甲酚 在 4-methylphenyl phosphate synthase 、 5’-三磷酸腺苷 、 magnesium chloride 、 manganese(ll) chloride 作用下， 以 aq. buffer 为溶剂， 反应 2.0h， 生成 o-cresyl dihydrogen phosphate
  参考文献：
  名称：

  通过化学模拟生物催化系统选择性氧化烷基酚中的脂肪族CH键

  摘要：

  烷基酚中脂族C–H键的选择性氧化不仅在可用于合成各种下游化学产品的功能化中间体的产生中，而且在这些对环境有害的化合物的生物降解中都起着重要作用。化学选择性，区域选择性和立体选择性；可控性 环境影响是烷基酚化学氧化的主要挑战。在这里，我们报道了一种源自革兰氏阳性细菌谷氨酸棒杆菌的独特化学模拟生物催化系统的发展。由CreHI（用于安装磷酸酯导向/锚定基团），CreJEF / CreG / CreC（用于烷基酚的氧化）和CreD（用于导向/锚定基团卸载）组成的系统能够选择性地氧化脂族C-H键的p -和米以可控的方式烷基化酚。此外，与两种代表性底物复合的中央P450生物催化剂CreJ的晶体结构为其底物的柔韧性和反应选择性提供了重要的结构见解。

  DOI：

  10.1073/pnas.1702317114

文献信息

• CARBONIC ACID ESTER AND MAGNETIC RECORDING MEDIUM
  申请人：IMAKUNI Akira

  公开号：US20080241599A1

  公开（公告）日：2008-10-02

  A carbonic acid ester is provided that is represented by the formula below and has a melting point of no greater than 0° C. (In the formula, R 1 and R 2 independently denote a saturated hydrocarbon group, R 1 is a branched chain, and R 2 is a straight or branched chain). There is also provided a magnetic recording medium that includes a non-magnetic support and, above the support, at least one magnetic layer including a ferromagnetic powder dispersed in a binder, the magnetic layer including the carbonic acid ester. Furthermore, there is provided a magnetic recording medium including a support and, above the support, a non-magnetic layer including a non-magnetic powder dispersed in a binder, and above the non-magnetic layer, at least one magnetic layer including a ferromagnetic powder dispersed in a binder, the non-magnetic layer and/or the magnetic layer including the carbonic acid ester.

  提供一种碳酸酯，其化学式如下，并且其熔点不大于0°C。（在化学式中，R1和R2分别表示饱和碳氢基团，R1是支链，R2是直链或支链）。还提供了一种磁记录介质，包括非磁性支撑物，在支撑物上方至少有一层包括铁磁粉末分散在粘合剂中的磁性层，该磁性层包括碳酸酯。此外，还提供了一种磁记录介质，包括支撑物，在支撑物上方有一层包括非磁性粉末分散在粘合剂中的非磁性层，以及在非磁性层上方，至少有一层包括铁磁粉末分散在粘合剂中的磁性层，其中非磁性层和/或磁性层包括碳酸酯。
• Structural effects in reactions of organophosphorus compounds. I. Reactions of phosphorus oxychloride with hindered phenols
  作者：Gennady M. Kosolapoff、Charles K. Arpke、Robert W. Lamb、Hans Reich

  DOI：10.1039/j39680000815

  日期：——

  2,6-Dialkyl-phenols exhibit little steric hindrance on reaction with phosphoryl chloride unless the alkyl substituent is bulky (i.e. t-butyl). Where bulky substituents are present reaction with phosphoryl chloride occurs only in the presence of Friedel–Crafts type catalysts after either a dealkylation or a rearrangement of the ortho-placed alkyl groups, followed by O-phosphorylation, has occurred.

  除非烷基取代基是大体积的（即叔丁基），否则2，6-二烷基苯酚与磷酰氯的反应几乎没有空间位阻。在存在大量取代基的情况下，只有在邻位烷基脱烷基或重排，然后进行O-磷酸化后，才在Friedel-Crafts型催化剂存在下与磷酰氯发生反应。
• Phosphoramidates and methods therefor
  申请人：——

  公开号：US20020004594A1

  公开（公告）日：2002-01-10

  Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs as their corresponding phosphate esters or amides. Described phosphoramidate compounds exhibit antiproliferative activity. Pharmaceutical formulations are provided for treatment of cancers.

  描述了羟基功能或氨基功能化合物的新型磷酰胺衍生物，包括氨基酸、肽、肽类似物和核苷酸类似物。这些化合物能够通过它们的相应磷酸酯或酰胺实现药物的增强细胞内递送。所述的磷酰胺化合物表现出抗增殖活性。提供了用于治疗癌症的药物配方。
• Process for producing poly(ethylene-aromatic dicarboxylate ester) resin and resin product
  申请人：——

  公开号：US20040254331A1

  公开（公告）日：2004-12-16

  A poly(ethylene aromatic dicarboxylate ester) resin usable for the production of fibers, films and bottle-formed articles, is produced by polycondensing a diester of an aromatic dicarboxylic acid with ethylene glycol by using a catalyst including a non-reacted mixture or reaction product of a titanium compound component including at least one member selected from titanium alkoxides and reaction products of the titanium alkoxides with aromatic polyvalent carboxylic acids or anhydrides thereof, with a specific phosphorus compound, in which catalyst the contents of titanium and phosphorus elements are controlled.

  一种聚乙烯芳香族二羧酸酯树脂，可用于生产纤维、薄膜和瓶形制品，通过使用包括钛化合物组分的催化剂，其中该组分包括至少选择自钛烷氧化物和钛烷氧化物与芳香族多价羧酸或其酐的反应产物的未反应混合物或反应产物，以及一种特定的磷化合物，通过控制钛和磷元素的含量，聚缩芳香族二羧酸的二酯和乙二醇。
• CARBONIC ACID ESTER, PRODUCTION PROCESS THEREFOR, AND MAGNETIC RECORDING MEDIUM
  申请人：MORI Masahiko

  公开号：US20080020243A1

  公开（公告）日：2008-01-24

  A process for producing a carbonic acid ester is provided, the process comprising a step of synthesizing a saturated alkyl carbonic acid ester represented by Formula (1) so as to give the saturated alkyl carbonic acid ester represented by Formula (1) as a crude product and a step of subjecting the crude product to liquid-liquid extraction using a saturated hydrocarbon solvent and a solvent comprising an organic solvent that is not infinitely miscible with the saturated hydrocarbon solvent so as to give the saturated alkyl carbonic acid ester represented by Formula (1) as a purified product (in Formula (1), R 1 and R 2 independently denote a saturated hydrocarbon group provided that the sum of the number of carbons in R 1 and the number of carbons in R 2 is at least 12 but no greater than 50). There are also provided a carbonic acid ester produced by the production process, and a magnetic recording medium comprising a non-magnetic support and, above the non-magnetic support, a magnetic layer comprising a ferromagnetic powder dispersed in a binder, the magnetic layer comprising the carbonic acid ester and having on the surface a number of protrusions that satisfies Formula (2) 0.01≦H 15 /H 10 <0.20   (2) (H 10 denotes the number of protrusions per unit area on the surface of the magnetic layer that have a height of less than 10 nm (number/μm 2 ), and H 15 denotes the number of protrusions per unit area on the surface of the magnetic layer that have a height of 15 nm or greater (number/μm 2 )).

  提供了一种制备碳酸酯的工艺，该工艺包括合成由式（1）表示的饱和烷基碳酸酯的步骤，以便将由式（1）表示的饱和烷基碳酸酯作为粗产品，并使用饱和烃溶剂和不与饱和烃溶剂无限混溶的有机溶剂的溶剂进行液-液萃取的步骤，以便将由式（1）表示的饱和烷基碳酸酯作为纯化产品（在式（1）中，R1和R2独立表示饱和烃基，但R1中碳数和R2中碳数之和至少为12但不大于50）。还提供了通过生产工艺生产的碳酸酯，以及包括非磁性支撑和在非磁性支撑上的磁性层的磁记录介质，其中磁性层包括分散在粘合剂中的铁磁性粉末，磁性层包括碳酸酯，并在表面具有满足公式（2）的许多突起0.01≦H15/H10<0.20（2）（其中H10表示磁性层表面每单位面积具有高度小于10 nm的突起的数量（数量/μm2），而H15表示磁性层表面每单位面积具有高度为15 nm或更高的突起的数量（数量/μm2））。