(-)-tropane-2-carboxylic acid

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: (-)-tropane-2-carboxylic acid
• 英文别名: (-)-Tropan-2-carbonsaeure；8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid
• 化学式: C₉H₁₅NO₂
• 分子量: 169.224
• InChiKey: TXSARNVUDNBDKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds and methods for preventing or treating sensory hair cell death
  申请人：UNIVERSITY OF WASHINGTON

  公开号：US10399994B2

  公开（公告）日：2019-09-03

  Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

  本文公开了用于预防或治疗听力损失的化合物以及包含此类化合物的药物组合物。本文所述的化合物和药物组合物可预防或治疗毛细胞死亡。此外，本文所述的化合物和药物组合物还能防止接受氨基糖苷类抗生素治疗的人的肾脏受损。还公开了单独使用或与其他治疗剂结合使用这些化合物的方法。
• COCAINE RECEPTOR BINDING LIGANDS
  申请人：RESEARCH TRIANGLE INSTITUTE

  公开号：EP0542903B1

  公开（公告）日：1996-11-13
• COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH
  申请人：University of Washington

  公开号：EP3253766B1

  公开（公告）日：2019-09-04
• INHIBITORS OF BRUTONS TYROSINE KINASE
  申请人：Pharmacyclics LLC

  公开号：US20210070748A1

  公开（公告）日：2021-03-11

  Disclosed herein are reversible and irreversible inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are described, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
• [EN] COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR PRÉVENIR OU TRAITER LA MORT DE CELLULES CAPILLAIRES SENSORIELLES
  申请人：UNIV WASHINGTON

  公开号：WO2016127123A2

  公开（公告）日：2016-08-11

  Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.