The present invention relates to an organic solvent-soluble mucopolysaccharide consisting of an ionic complex of at least one mucopolysaccharide (preferably heparin or heparin derivative) and a quaternary phosphonium, an antibacterial antithrombogenic composition comprising said organic solvent-soluble mucopolysaccharide and an organic polymer material, an antibacterial antithrombogenic composition comprising said organic solvent-soluble mucopolysaccharide and an antibacterial agent (preferably inorganic antibacterial agent such as silver zeolite), and to a medical material comprising said organic solvent-soluble mucopolysaccharide. The organic solvent-soluble mucopolysaccharide, and the antibacterial antithrombogenic composition and medical material containing the same, of the present invention, can easily impart antithrombogenicity and antibacterial property to a polymer to be a base material, which properties being maintained not only immediately after preparation of the material but also after long-term elution. Thus, the organic solvent-soluble mucopolysaccharide and antibacterial antithrombogenic material of the present invention show superior applicability as a material to impart antithrombogenicity and antibacterial ability to medical materials.
本发明涉及一种有机溶剂可溶性粘
多糖,由至少一种粘
多糖(优选
肝素或
肝素衍
生物)和季
鏻的离子复合物组成;一种抗菌抗血栓形成组合物,由所述有机溶剂可溶性粘
多糖和有机聚合物材料组成、由所述有机溶剂溶性粘
多糖和抗菌剂(最好是无机抗菌剂,如
银沸石)组成的抗菌抗血栓形成组合物,以及由所述有机溶剂溶性粘
多糖组成的医用材料。本发明的有机溶剂溶性粘
多糖、抗菌抗血栓形成组合物和含有该粘
多糖的医用材料可以很容易地将抗血栓形成性和抗菌性赋予作为基础材料的聚合物,这些特性不仅在制备材料后立即保持,而且在长期洗脱后也能保持。因此,本发明的有机溶剂溶性粘
多糖和抗菌抗血栓材料作为赋予医用材料抗血栓和抗菌能力的材料,显示出优越的适用性。