18F-Fpcit

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 18F-Fpcit
• 英文别名: methyl 8-(3-(18F)fluoranylpropyl)-3-(4-iodophenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
• 化学式: C18H23FINO2
• 分子量: 430.3
• InChiKey: HXWLAJVUJSVENX-AWDFDDCISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• METHOD FOR THE SYNTHESIS OF 18F-LABELLED BIOMOLECULES
  申请人：GE HEALTHCARE LIMITED

  公开号：US20140235861A1

  公开（公告）日：2014-08-21

  The present invention provides a method for the synthesis of 18 F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised.
• METHOD FOR THE SYNTHESIS OF 18F-LABELLED MOLECULES
  申请人：GE HEALTHCARE LIMITED

  公开号：US20140243555A1

  公开（公告）日：2014-08-28

  The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised.
• METHOD FOR SYNTHESIZING RADIOPHARMACEUTICALS USING A CARTRIDGE
  申请人：Futurechem Co., LTD.

  公开号：US20150232392A1

  公开（公告）日：2015-08-20

  The present invention relates to a method for synthesizing a radiopharmaceutical using a cartridge, which makes it possible to carry out several steps of reaction required for synthesizing a radiopharmaceutical in the cartridge filled with a polymer. A method for synthesizing a radiopharmaceutical according to the present invention enables each step's reaction to be carried out with the solution confined in the cartridge so as not to flow out, thus being simplified compared to the conventional methods for synthesizing radiopharmaceuticals, and expediting the synthesis thereof.
• US9085518B2
  申请人：——

  公开号：US9085518B2

  公开（公告）日：2015-07-21
• US9125954B2
  申请人：——

  公开号：US9125954B2

  公开（公告）日：2015-09-08