p-Nitrophenyl-m-fluorbenzoat | 35666-15-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: p-Nitrophenyl-m-fluorbenzoat
• 英文别名: 3-Fluorobenzoic acid, 4-nitrophenyl ester；(4-nitrophenyl) 3-fluorobenzoate
• CAS: 35666-15-0
• 化学式: C₁₃H₈FNO₄
• 分子量: 261.209
• InChiKey: SUBDOSZYYCCUGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Novel method for the production of 18F-labeled active esters and their application exemplified by the preparation of a PSMA-specific PET-tracer
  申请人：Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.

  公开号：US20170267717A1

  公开（公告）日：2017-09-21

  Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18 F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18 F − are described. The active ester including [ 18 F]F-Py-TFP and [ 18 F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [ 18 F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor.