p-Fluoroatropine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: p-Fluoroatropine
• 英文别名: (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-(4-fluorophenyl)-3-hydroxypropanoate
• 化学式: C₁₇H₂₂FNO₃
• 分子量: 307.36
• InChiKey: SKYKNOOJEBRZQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compounds, Compositions and Methods for Treatment of Myopia
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US20200247760A1

  公开（公告）日：2020-08-06

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

  本文提供了8-甲基-8-氮杂双环[3.2.1]辛烷-3-基和吡啶-4-甲基酯和酰胺化合物及其组合物。本文还提供了一种预防或延迟需要该治疗的患者近视发生的方法，包括向该患者施用本文提供的化合物或组合物。本文还提供了一种减缓或预防需要该治疗的患者近视进展的方法，包括向该患者施用本文提供的化合物或组合物。
• Compounds, compositions and methods for treatment of myopia
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：US11117869B2

  公开（公告）日：2021-09-14

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.

  本文提供了8-甲基-8-氮杂双环[3.2.1]辛烷-3-基和吡啶-4-基甲烷酯和酰胺化合物及组合物。本文还提供了预防或延迟有需要的受试者近视发生的方法，包括向受试者施用本文提供的化合物或组合物。本文还提供了减少或预防有需要的受试者近视发展的方法，包括对受试者施用本文提供的化合物或组合物。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF MYOPIA
  申请人：Aerie Pharmaceuticals, Inc.

  公开号：EP3917923A2

  公开（公告）日：2021-12-08
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF MYOPIA<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE LA MYOPIE
  申请人：AERIE PHARMACEUTICALS INC

  公开号：WO2020160493A2

  公开（公告）日：2020-08-06

  Provided herein are 8-methyl-8-azabicyclo[3.2.1]octan-3-yl and pyridin-4-ylmethanyl ester and amide compounds and compositions. Also provided herein are methods of preventing or delaying the onset of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject. Also provided herein are methods of reducing or preventing the progression of myopia in a subject in need thereof, comprising administering the compounds or compositions provided herein to the subject.