6-amino-1',2-dimethylspiro[3,8a-dihydro-1H-isoquinoline-8,4'-piperidine]-5,7,7-tricarbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂螺癸烷衍生物
• 英文名称: 6-amino-1',2-dimethylspiro[3,8a-dihydro-1H-isoquinoline-8,4'-piperidine]-5,7,7-tricarbonitrile
• 化学式: C₁₈H₂₂N₆
• 分子量: 322.413
• InChiKey: OKZFPFAXXPZZIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-amino-1',2-dimethylspiro[3,8a-dihydro-1H-isoquinoline-8,4'-piperidine]-5,7,7-tricarbonitrile 、 2-(5-chloro-2-oxoindolin-3-ylidene)malononitrile 在 三乙胺 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Novel route to spiropiperidines using N-methyl-4-piperidone, malononitrile and electrophiles

  摘要：

  A new pathway to spiropiperidine rings via sequential one pot reaction of N-methyl-4-piperidone, malononitrile, and electrophiles or Michael acceptor in the presence of triethyl amine in ethanol under reflux condition is reported. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.129
• 作为产物：
  描述：

  N-甲基-4-哌啶酮 、 丙二腈 生成 6-amino-1',2-dimethylspiro[3,8a-dihydro-1H-isoquinoline-8,4'-piperidine]-5,7,7-tricarbonitrile
  参考文献：
  名称：

  An efficient synthesis of fluorine-containing substituted spiro[piperidine-4,4′-pyrano[3,2-c]quinoline]-3′-carbonitrile by nonconventional methods

  摘要：

  A series of fluorine-containing substituted spiro[piperidine-4,4'-pyrano[3,2-c]quinolines] were synthesized through a rapid one-pot multicomponent reaction under microwave irradiation and sonication. The method has the advantages of excellent yields (80-96%) and short reaction time (3-10 min). We provide a series of fluorinated quinoline derivatives interesting for biological screening tests. (C) 2007 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2007.08.002

文献信息

• One-step synthesis of substituted 4,8-dihydropyrano[3,2-b]pyran-4-ones
  作者：A. A. Shestopalov、L. A. Rodinovskaya、A. M. Shestopalov、V. P. Litvinov

  DOI：10.1023/b:rucb.0000035666.05686.89

  日期：2004.3