1-[(1R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]ethanone

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 托烷生物碱
• 英文名称: 1-[(1R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]ethanone
• 化学式: C₉H₁₅NO₂
• 分子量: 169.22
• InChiKey: OSKMTRDBLAVUMD-JVHMLUBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PROTEASOME ACTIVITY ENHANCING COMPOUNDS
  申请人：Proteostasis Therapeutics, Inc.

  公开号：US20210115057A1

  公开（公告）日：2021-04-22

  The present invention is directed to compounds having the Formulae (Ia), (Ib), (Ic), or (Id); or the Formulae (II), (IIa), (IIb), or (IIc); or the Formulae (III), (IIIa), (IIIb), (IIIc), (IIId), or (IIIe), and pharmaceutically acceptable salts, solvates, clathrates and prodrugs of any Formula thereof, compositions thereof, and methods for the treatment of a condition associated with a dysfunction in proteostasis.