Phenyl 4-butoxybenzoate | 103749-60-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: Phenyl 4-butoxybenzoate
• 英文别名: 4-butoxy-benzoic acid phenyl ester；4-Butoxy-benzoesaeure-phenylester
• CAS: 103749-60-6
• 化学式: C₁₇H₁₈O₃
• 分子量: 270.328
• InChiKey: MLECIZGZWCAVSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Phenyl 4-butoxybenzoate 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (4-butoxy-benzoyl)-sulfanilyl-amine
  参考文献：
  名称：

  Proteolytic processing of human growth hormone (GH) by rat tissues in vitro: Influence of sex and age

  摘要：

  Although a wealth of evidence exists indicating that proteolytic cleavage can enhance the biological activity of the growth hormone (GH) molecule, the mechanisms responsible for the generation of GH fragments are not completely understood. In the present work we investigated the ability of different rat tissues to cleave 22 kDa GH, as well as the influence of sex and age, the two major physiological regulators of GH secretion on this process. Our results show that tissue homogenates obtained from rat liver, skeletal muscle or adipose tissue (three well-documented target organs for the hormone) are able to cleave 22K-GH, while the hormone is resistant to cleavage by rat brain homogenates. This process is rather selective for 22K-GH, since the 20 kDa GH variant exhibits stability to degradation by all tissue homogenates investigated. Moreover, only a minor fraction of 22 kDa GH is cleaved under our experimental conditions, suggesting that GH microheterogeneity within the 22 kDa range may also determine hormone susceptibility. Finally, we also found that 22K-GH processing shows important age-related changes (the greatest intensity observed in 4-day-old pups), while no gender-related differences exist in any of the tissues investigated. (C) 2000, Editrice Kurtis.

  DOI：

  10.1007/bf03345065
• 作为产物：
  描述：

  4-正丁氧基苯甲酰氯 、 苯酚 在 sodium hydroxide 作用下， 以47.5%的产率得到Phenyl 4-butoxybenzoate
  参考文献：
  名称：

  Substituent Effects on the Base-Catalysed Hydrolysis of Phenyl Esters of para-Substituted Benzoic Acids

  摘要：

  4-取代苯甲酸的17种模型苯酯通过取代苯甲酰氯与酚在水性碱性溶液中（Schotten-Baumann反应），在吡啶中（Einhorn反应），或通过取代苯甲酸与氯化亚磷酸反应合成。模型化合物的结构和纯度通过¹H NMR和¹³C NMR光谱以及HPLC和元素分析得到确认。苯基4-氨基苯甲酸是通过在钯上在甲醇中还原苯基4-硝基苯甲酸合成的。在25°C下，通过伪一级条件（c[NaOH] = 0.001-1.0 mol l^-1）在50%（体积比）水性二甲基亚砜溶液中，利用UV分光光度法测量了发生B_Ac2机制的模型苯酯的碱催化水解动力学。将OH^-加入苯基苯甲酸酯以建立动力学J_-^E酸度标度。对于所有模型化合物，发现了J_-^E与log k_obs之间的线性关系，斜率接近于单位。4-取代苯甲酸酯的水解动力学常数精确遵守Hammett关系（σ_p），ρ = 2.44。使用σⁱ取代基常数集合，通过应用替代取代基效应理论（AISE），获得了定量可比较的结果。

  DOI：

  10.1135/cccc20001777

文献信息

• Process for preparing polycarbonate and apparatus for preparing polycarbonate
  申请人：General Electric Company

  公开号：US20030088051A1

  公开（公告）日：2003-05-08

  A process for preparing an end-capped polycarbonate comprises melt reacting an aromatic dihydroxy compound, a carbonic acid diester, and optionally a catalyst in a prepolymerization vessel to form a polycarbonate product; transferring the polycarbonate product from the prepolymerization vessel; mixing the polycarbonate product with an end-capping agent under hermetic seal at a pressure of at least about 760 mm Hg; and transferring the polycarbonate product and end-capping agent mixture to a postpolymerization vessel to endcap the polycarbonate product. An apparatus for preparing an end-capped polycarbonate comprises a prepolymerization vessel having and inlet and an outlet; a postpolymerization vessel having an inlet and an outlet; a mixer in fluid communication with the outlet of the prepolymerization vessel and the inlet of the postpolymerization vessel; and a charging port through which an end-capping agent is charged to the mixer, wherein the mixer is hermetically sealed at greater than or equal to 760 mm Hg.

  一种制备封端聚碳酸酯的工艺包括：在预聚合容器中熔融反应芳香族二羟基化合物、碳酸二酯和催化剂，形成聚碳酸酯产品；将聚碳酸酯产品从预聚合容器中转移出来；在至少约 760 毫米汞柱的压力下，在密封条件下将聚碳酸酯产品与封端剂混合；以及将聚碳酸酯产品和封端剂混合物转移到后聚合容器中，对聚碳酸酯产品进行封端。一种用于制备端盖聚碳酸酯的设备包括：一个具有入口和出口的预聚合容器；一个具有入口和出口的后聚合容器；一个与预聚合容器的出口和后聚合容器的入口流体相通的混合器；以及一个将端盖剂装入混合器的装料口，其中混合器在大于或等于 760 毫米汞柱的压力下密封。
• PROCESS FOR PREPARING POLYCARBONATE AND APPARATUS FOR PREPARING POLYCARBONATE
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP1412411A2

  公开（公告）日：2004-04-28
• US3981856A
  申请人：——

  公开号：US3981856A

  公开（公告）日：1976-09-21
• US4495311A
  申请人：——

  公开号：US4495311A

  公开（公告）日：1985-01-22
• US6620902B2
  申请人：——

  公开号：US6620902B2

  公开（公告）日：2003-09-16