5-(4-Methylphenyl)-3-(2-oxo-2-piperidin-1-ylethyl)thieno[2,3-d]pyrimidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 5-(4-Methylphenyl)-3-(2-oxo-2-piperidin-1-ylethyl)thieno[2,3-d]pyrimidin-4-one
• 化学式: C₂₀H₂₁N₃O₂S
• 分子量: 367.5
• InChiKey: GLDIXYQWTJNSSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  81.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Thienopyrimidinone NMDA receptor modulators and uses thereof
  申请人：Cadent Therapeutics, Inc.

  公开号：US10973825B2

  公开（公告）日：2021-04-13

  Disclosed herein, in part, are methods of treating neurological disorders, e.g., schizophrenia and major depressive disorder, comprising administering an effective amount of a disclosed heterocyclic compound. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated to modulate the NMDA receptor.

  本文部分公开了治疗神经系统疾病（如精神分裂症和重度抑郁症）的方法，包括施用有效量的已公开杂环化合物。提供了药物组合物和制造杂环化合物的方法。这些化合物可用于调节 NMDA 受体。
• THIENOPYRIMIDINONE NMDA RECEPTOR MODUCLATORS AND USES THEREOF
  申请人：CADENT THERAPEUTICS, INC.

  公开号：US20180360837A1

  公开（公告）日：2018-12-20

  Disclosed herein, in part, are methods of treating neurological disorders, e.g., schizophrenia and major depressive disorder, comprising administering an effective amount of a disclosed heterocyclic compound. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated to modulate the NMDA receptor.
• THIENOPYRIMIDINONE NMDA RECEPTOR MODULATORS AND USES THEREOF
  申请人：Cadent Therapeutics, Inc.

  公开号：US20220016117A1

  公开（公告）日：2022-01-20

  Disclosed herein, in part, are methods of treating neurological disorders, e.g., schizophrenia and major depressive disorder, comprising administering an effective amount of a disclosed heterocyclic compound. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated to modulate the NMDA receptor.